Title |
Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients.
|
---|---|
Published in |
Current Drug Targets, January 2017
|
DOI | 10.2174/1389450117666160208145934 |
Pubmed ID | |
Authors |
Nadya Velikova, Jerry M Wells |
Abstract |
Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkholderia cepacia complex and especially Pseudomonas aeruginosa are more frequently seen. P. aeruginosa is a turning point in the respiratory disease in CF and its predominance increases with age. Bacteria use a variety of two-component systems (TCS) to differentially express virulence factors involved in both acute and chronic infections. Here, we review bacterial TCS as targets for antibacterial treatment for CF patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 15% |
Student > Master | 3 | 15% |
Student > Ph. D. Student | 2 | 10% |
Lecturer | 1 | 5% |
Librarian | 1 | 5% |
Other | 3 | 15% |
Unknown | 7 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 20% |
Immunology and Microbiology | 3 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 35% |