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Mendeley readers
Attention Score in Context
| Title |
The Relationship Between Plasma Aβ Levels, Cognitive Function and Brain Volumetrics: Sydney Memory and Ageing Study.
|
|---|---|
| Published in |
Current Alzheimer Research, January 2016
|
| DOI | 10.2174/1567205013666151218150202 |
| Pubmed ID | |
| Authors |
Anne Poljak, John D Crawford, George A Smythe, Henry Brodaty, Melissa J Slavin, Nicole A Kochan, Julian N Trollor, Wei Wen, Karen A Mather, Amelia A Assareh, Pek C Ng, Perminder S Sachdev |
| Abstract |
Objectives Determine whether (1) a relationship exists between plasma amyloid-β (Aβ1-40 and 1-42 peptide levels, brain volumetrics and cognitive performance in elderly individuals with and without amnestic mild cognitive impairment (aMCI), (2) plasma Aβ peptide levels differ between apolipoprotein E (APOE) β4 carriers and non-carriers and (3) longitudinal changes in cognition and brain volume relate to Aβ levels. Methods Subjects with aMCI (n = 89) and normal cognition (n = 126) were drawn from the Sydney Memory and Aging Study (Sydney MAS), a population based study of non-demented 70-90 year old individuals; 39 Alzheimer's disease (AD) patients were recruited from a specialty clinic. Sydney MAS participants underwent brain MRI scans and were assessed on 19 cognitive measures and were APOE β4 genotyped. Plasma levels of Aβ1-40 and 1-42 were quantified using ELISA. Results Wave1 plasma levels of A peptides and Aβ 42/1-40 ratio were lower in aMCI and AD, and Aβ 42 was positively associated with global cognition and hippocampal volume and negatively with white matter hyperintensities. The relationships of Aβ1-40 and Aβ1-42 were predominantly observed in β4 allele carriers and non-carriers respectively. Longitudinal analysis revealed greater decline in global cognition and memory for the highest quintiles of Aβ42 and the ratio measure. Conclusions Plasma Aβ levels and the Aβ42/1-40 ratio are related to cognition and hippocampal volumes, with differential associations of Aβ1-40 and Aβ1-42 in β4 carriers and non-carriers. These data support the Aβ sink model of AD pathology, and suggest that plasma Aβ measures may serve as biomarkers of AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 16% |
| Researcher | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Student > Ph. D. Student | 6 | 11% |
| Student > Doctoral Student | 3 | 5% |
| Other | 7 | 13% |
| Unknown | 17 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 16% |
| Psychology | 7 | 13% |
| Medicine and Dentistry | 6 | 11% |
| Agricultural and Biological Sciences | 4 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 23 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2016.
All research outputs
#1,107,037
of 25,377,790 outputs
Outputs from Current Alzheimer Research
#24
of 1,177 outputs
Outputs of similar age
#18,955
of 399,683 outputs
Outputs of similar age from Current Alzheimer Research
#3
of 117 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,177 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,683 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.