Title |
CD4+ T-cell Count may not be a Useful Strategy to Monitor Antiretroviral Therapy Response in HTLV-1/HIV Co-infected Patients.
|
---|---|
Published in |
Current HIV Research, January 2017
|
DOI | 10.2174/1570162x15666170216114917 |
Pubmed ID | |
Authors |
Alain Vandormael, Filipe Rego, Siva Danaviah, Luiz Carlos Junior Alcantara, David R Boulware, Tulio de Oliveira |
Abstract |
HTLV-1/HIV co-infection is known to elevate the CD4+ T-cell counts of treatment-naïve persons. We investigated whether HTLV-1/HIV co-infected patients continued to have elevated CD4+ T-cell counts after developing virologic failure on antiretroviral therapy (ART). The data comes from a drug resistance study located in the KwaZulu-Natal province of South Africa. All participants (N=383) presented for repeated CD4+ T-cell count and HIV viral load level testing between January 2006 and March 2014. We used a random-coefficient model to estimate the change in CD4+ T-cell count and HIV viral load level by HTLV-1/HIV co-infection status over time, adjusting for age, sex, and duration of virologic failure. HTLV-1/HIV co-infected participants (n=8) had higher CD4+ T-cell counts, with a positive difference of 117.2 cells/µL at the ART initiation date (p-value=0.001), 114.7 cells/µL (p-value<0.001) 12 months after this date, and 112.3 cells/µL (p-value=0.005) 24 months after this date, holding all else constant. In contrast, there was no difference in the HIV viral load level by HTLV-1/HIV co-infected status throughout the observation period. We show that HTLV-1/HIV co-infected participants continued to have elevated CD4+ T-cell counts after developing virologic failure on ART, despite no difference in their HIV viral load levels when compared with HIV mono-infected participants. Our results indicate that CD4+ T-cell count testing may not be a useful strategy to monitor ART response in the presence of HTLV-1 infection. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 18% |
Student > Ph. D. Student | 4 | 14% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Lecturer | 2 | 7% |
Other | 6 | 21% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 25% |
Nursing and Health Professions | 4 | 14% |
Immunology and Microbiology | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Computer Science | 1 | 4% |
Other | 3 | 11% |
Unknown | 9 | 32% |