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IMMUNE RESPONSE OF SEVERE MALNUTRITION CHILDREN TREATED ACCORDING TO THE PROTOCOL OF THE WORLD HEALTH ORGANIZATION.

Overview of attention for article published in Nutrición Hospitalaria, August 2015
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Title
IMMUNE RESPONSE OF SEVERE MALNUTRITION CHILDREN TREATED ACCORDING TO THE PROTOCOL OF THE WORLD HEALTH ORGANIZATION.
Published in
Nutrición Hospitalaria, August 2015
DOI 10.3305/nh.2015.32.2.9048
Pubmed ID
Authors

Rebecca Peixoto Paes-Silva, Érika Michelle Correia de Macedo, Marília Tokiko Oliveira Tomiya, Célia Maria Machado Barbosa de Castro

Abstract

The aim of the study was to compare the innate immune system of severely malnourished children admitted to the Instituto de Medicina Integral Professor Fernando Figueira and treated according to the protocol of the World Health Organization (WHO) at admission and discharge. An experimental study was conducted with 20 children under two years of age. Ten of them had severe malnutrition and ten were a control group. The malnourished group consisted of hospitalized infants and it was submitted to WHO's protocol. Children with HIV and re-admitted during the study period were excluded. A blood sample was taken at admission and at discharge. Later, an analysis of blood leukocytes, adherence index, phagocytic capacity, production of free radicals superoxide and nitric oxide was performed. Patients with severe malnutrition at hospital discharge showed improved phagocytic function, release of oxygen radicals and reduction of the number of lymphocytes when compared to the time of admission. When compared to the control group, patients at hospital discharge had lower lymphocyte values and lower production of free radicals. Thus, it can be concluded that the duration of hospitalization was insufficient to restore cell-mediated immunity and microbicide activity.

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Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 24%
Student > Master 8 17%
Student > Doctoral Student 4 9%
Other 2 4%
Student > Ph. D. Student 2 4%
Other 4 9%
Unknown 15 33%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 17%
Medicine and Dentistry 7 15%
Immunology and Microbiology 5 11%
Nursing and Health Professions 4 9%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 3 7%
Unknown 17 37%