Title |
Successful treatment of fungal endophthalmitis using intravitreal caspofungin
|
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Published in |
Arquivos Brasileiros de Oftalmologia, January 2017
|
DOI | 10.5935/0004-2749.20170048 |
Pubmed ID | |
Authors |
Ciprian Danielescu, Alina Cantemir, Dorin Chiselita |
Abstract |
Fungal endophthalmitis is a rare condition often associated with poor prognosis. We present a case of postoperative acute fungal endophthalmitis caused by the yeast-like fungus Stephanoascus ciferrii (Candida ciferrii). The fungus was resistant to fluconazole, voriconazole, and amphotericin B but susceptible to caspofungin. Because the degree of vitreal penetration of caspofungin after its intravenous administration is unclear, we performed multiple intravitreal injections, first with 50 µg/0.1 ml and then with 250 µg/0.1 ml caspofungin. Despite the recurrence of symptoms, intravitreal injection of caspofungin finally abolished the inflammation and achieved ambulatory vision that persisted until 1 year of follow-up. To our knowledge, this is the first report of S. ciferrii endophthalmitis and its successful treatment with intravitreal caspofungin. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 13 | 100% |
Demographic breakdown
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Other | 3 | 23% |
Student > Bachelor | 2 | 15% |
Student > Doctoral Student | 1 | 8% |
Student > Master | 1 | 8% |
Student > Postgraduate | 1 | 8% |
Other | 0 | 0% |
Unknown | 5 | 38% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 54% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Unknown | 5 | 38% |