Title |
Nefrotoxicidade aguda da cisplatina: mecanismos moleculares
|
---|---|
Published in |
Jornal Brasileiro de Nefrologia, December 2013
|
DOI | 10.5935/0101-2800.20130052 |
Pubmed ID | |
Authors |
Luis Alberto Batista Peres, Ademar Dantas da Cunha Júnior |
Abstract |
The nephrotoxic drugs have been responsible for about 20% of AKI episodes in inpatients and outpatients. The cisplatin nephrotoxicity is a major limiting factors in 20% of patients who have received the drug, triggering injuries in renal tubular epithelial cells. Cisplatin toxicity is determined by the target tissue and cells accumulation besides the interaction with various subcellular structures and macromolecules. Cisplatin accumulates and interferes with the functioning of different organelles such as mitochondria, lysosomes, endoplasmic reticulum, nuclei and cell membranes, causing inflammation and cell death. This review aims to define the pathophysiology and biochemistry of the cisplatin nephrotoxicity, reviewing the main molecular mechanisms that lead to tubular cisplatin toxicity. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 196 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 31 | 16% |
Student > Bachelor | 30 | 15% |
Researcher | 19 | 10% |
Student > Ph. D. Student | 17 | 9% |
Other | 8 | 4% |
Other | 25 | 13% |
Unknown | 66 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 36 | 18% |
Biochemistry, Genetics and Molecular Biology | 22 | 11% |
Medicine and Dentistry | 22 | 11% |
Agricultural and Biological Sciences | 17 | 9% |
Chemistry | 11 | 6% |
Other | 15 | 8% |
Unknown | 73 | 37% |