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Fatores de risco associados à lesão renal aguda em pacientes tratados com polimixina B em um hospital terciário

Overview of attention for article published in Jornal Brasileiro de Nefrologia, January 2015
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Title
Fatores de risco associados à lesão renal aguda em pacientes tratados com polimixina B em um hospital terciário
Published in
Jornal Brasileiro de Nefrologia, January 2015
DOI 10.5935/0101-2800.20150071
Pubmed ID
Authors

Laura Fuchs Bahlis, Luciano Passamani Diogo, Daniel Lemons, Denise Klaus

Abstract

Polimyxins were originally abandoned due to high rates of nephrotoxicity. However they have been recently reintroduced due to activity against carbapenem-resistant Gram-negative organisms. Recent literature suggests a lower rate of nephrotoxicity than historically reported. To determine the rate of polymixins-associated nephrotoxicity as defined by the RIFLE criteria. A retrospective cohort of all adult patients who received polymixin B at a terciary hospital from December 2010 to March 2011was performed. 61 patients (43%) fulfilled the RIFLE criteria for renal injury and 28 patients (13.7%) needed dialysis. Independent predictors for nephrotoxicity were hypotension (OR, 2.79; CI 1.14-5.8; p = 0.006) and concomitant use of vancomycin (OR, 2.86; CI, 1.27-6.4; p = 0.011). In this retrospective cohort, nephrotoxicity (as defined by RIFLE criteria) occurred among 43% of treated patients. The concomitant use of vancomycin and hypotension were independent risk factors of nephropathy. Further studies are needed, particularly with polymyxin B, to clarify if the characteristics of this drug and colistin are overlapping.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 27%
Student > Bachelor 4 15%
Other 3 12%
Researcher 3 12%
Student > Ph. D. Student 2 8%
Other 1 4%
Unknown 6 23%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 27%
Nursing and Health Professions 4 15%
Medicine and Dentistry 4 15%
Immunology and Microbiology 2 8%
Psychology 1 4%
Other 1 4%
Unknown 7 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2015.
All research outputs
#15,533,143
of 25,394,764 outputs
Outputs from Jornal Brasileiro de Nefrologia
#122
of 366 outputs
Outputs of similar age
#191,095
of 359,691 outputs
Outputs of similar age from Jornal Brasileiro de Nefrologia
#7
of 26 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 366 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,691 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.