Title |
Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome
|
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Published in |
Clinics, March 2014
|
DOI | 10.6061/clinics/2014(03)06 |
Pubmed ID | |
Authors |
Gustavo A Rosa Maciel, Ricardo P P Moreira, Diogo D G Bugano, Sylvia A Y Hayashida, José A M Marcondes, Larissa G Gomes, Berenice B Mendonça, Tânia A S S Bachega, Edmund C Baracat |
Abstract |
We aimed to investigate whether glucocorticoid receptor gene polymorphisms are associated with clinical and metabolic profiles in patients with polycystic ovary syndrome. Polycystic ovary syndrome is a complex endocrine disease that affects 5-8% of women and may be associated with metabolic syndrome, which is a risk factor for cardiovascular disease. Cortisol action and dysregulation account for metabolic syndrome development in the general population. As glucocorticoid receptor gene (NR3C1) polymorphisms regulate cortisol sensitivity, we hypothesized that variants of this gene may be involved in the adverse metabolic profiles of patients with polycystic ovary syndrome. |
X Demographics
Geographical breakdown
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 15 | 25% |
Student > Master | 8 | 13% |
Student > Ph. D. Student | 6 | 10% |
Unspecified | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 7 | 12% |
Unknown | 17 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 18% |
Nursing and Health Professions | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Agricultural and Biological Sciences | 5 | 8% |
Unspecified | 4 | 7% |
Other | 6 | 10% |
Unknown | 19 | 32% |