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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Use of cyclodextrins as excipients in pharmaceutical products: why not in extemporaneous preparations?
|
|---|---|
| Published in |
Farmacia Hospitalaria, November 2021
|
| DOI | 10.7399/fh.11728 |
| Pubmed ID | |
| Authors |
Beatriz Ramos-Martínez, Carmela Dávila-Pousa, Vicente Merino-Bohórquez, Marta García-Palomo, M ª Pilar Flox-Benítez |
| Abstract |
To conduct an assessment of cyclodextrins used as excipients in pharmaceutical formulations, considering compounding, iopharmaceuticalpharmacokinetic, toxicological, regulatory, economic and commercial aspects. A literature search was performed of highly cited review and original articles. Regulatory and legislative documents and well-established pharmacopoeias were also consulted. Solubility, resistance to hydrolysis and complexation efficiency are variables that depend on the cyclodextrin itself and on the drug to be complexed. In some cases, addition of excipients is necessary to improve complexation efficiency. Complexation of drugs with cyclodextrins at laboratory scale tends to be rather inconsistent. Moreover, wide variations exist for the same cyclodextrin across different suppliers and even across batches from the same supplier. This means more control analyses must be carried out of pharmaceutical preparations. Problems with the stability of cyclodextrin-drug complexes could affect the oral bioavailability of the drugs. Additionally, some cyclodextrins may optimize the drug's permeability through specific biological membranes and the length of time it remains in contact with them. Despite the safety profile of cyclodextrins, exceeding certain dosing thresholds and administration times might cause adverse effects. Only cyclodextrins recognized as excipients by well-esta blished pharmacopeias should be used in pharmaceutical compounding. Cyclodextrins lead to an increase in the global costs of compounding and their purchase through recognized suppliers is often unfeasible. Despite their interesting properties as excipients due to inclusion complex formation, the need to carry out more quality control analyses and stability constant studies, combined with the high cost and difficulty to purchase cyclodextrins, may explain why their use in pharmaceutical compounding is currently not a viable alternative. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 11% |
| Other | 1 | 5% |
| Researcher | 1 | 5% |
| Professor > Associate Professor | 1 | 5% |
| Student > Postgraduate | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 13 | 68% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 2 | 11% |
| Medicine and Dentistry | 2 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Engineering | 1 | 5% |
| Unknown | 13 | 68% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2022.
All research outputs
#20,673,680
of 25,392,582 outputs
Outputs from Farmacia Hospitalaria
#239
of 368 outputs
Outputs of similar age
#325,497
of 435,123 outputs
Outputs of similar age from Farmacia Hospitalaria
#6
of 9 outputs
Altmetric has tracked 25,392,582 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 368 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 435,123 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.