Title |
Off-label and unlicensed utilization of drugs in a Brazilian pediatric hospital
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Published in |
Farmacia Hospitalaria, May 2015
|
DOI | 10.7399/fh.2015.39.3.8472 |
Pubmed ID | |
Authors |
Vanessa Pereira Gomes, Kédma Melo da Silva, Suely Oliveira Chagas, Igor Rafael dos Santos Magalhães |
Abstract |
To describe the off-label and unlicensed utilization patterns of drugs in a Brazilian pediatric hospital. The research consisted of a descriptive, prospective and cross-sectional study. A total of 1,158 medicines were prescribed for 320 patients, accounting for 65 different drugs. Regarding the classification of drug utilization, the majority of the drugs were prescribed as in-label (57.2%), followed by off-label (36.4%) and by unlicensed (6.3%). The prevalences of unlicensed and off-label utilization of drugs in the studied population were 20.9 and 77.8%, respectively. Polypharmacy was highly associated to both off-label and unlicensed regimen (OR 12.9; 95% CI 3.07-54.2 and OR 3.68; 95% CI 2.02-6.69, respectively) whereas preschool children were less prone to unlicensed prescription (OR 0.39; 95% CI 0.19-0.79). Sex and length of hospitalization were not related to these outcomes. Further studies are necessary to verify the impact of this pattern on the occurrence of adverse drug events. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 26% |
Student > Bachelor | 8 | 16% |
Student > Ph. D. Student | 7 | 14% |
Other | 4 | 8% |
Student > Doctoral Student | 2 | 4% |
Other | 5 | 10% |
Unknown | 11 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 34% |
Medicine and Dentistry | 10 | 20% |
Chemistry | 2 | 4% |
Social Sciences | 2 | 4% |
Nursing and Health Professions | 1 | 2% |
Other | 4 | 8% |
Unknown | 14 | 28% |