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Off-label and unlicensed utilization of drugs in a Brazilian pediatric hospital

Overview of attention for article published in Farmacia Hospitalaria, May 2015
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Title
Off-label and unlicensed utilization of drugs in a Brazilian pediatric hospital
Published in
Farmacia Hospitalaria, May 2015
DOI 10.7399/fh.2015.39.3.8472
Pubmed ID
Authors

Vanessa Pereira Gomes, Kédma Melo da Silva, Suely Oliveira Chagas, Igor Rafael dos Santos Magalhães

Abstract

To describe the off-label and unlicensed utilization patterns of drugs in a Brazilian pediatric hospital. The research consisted of a descriptive, prospective and cross-sectional study. A total of 1,158 medicines were prescribed for 320 patients, accounting for 65 different drugs. Regarding the classification of drug utilization, the majority of the drugs were prescribed as in-label (57.2%), followed by off-label (36.4%) and by unlicensed (6.3%). The prevalences of unlicensed and off-label utilization of drugs in the studied population were 20.9 and 77.8%, respectively. Polypharmacy was highly associated to both off-label and unlicensed regimen (OR 12.9; 95% CI 3.07-54.2 and OR 3.68; 95% CI 2.02-6.69, respectively) whereas preschool children were less prone to unlicensed prescription (OR 0.39; 95% CI 0.19-0.79). Sex and length of hospitalization were not related to these outcomes. Further studies are necessary to verify the impact of this pattern on the occurrence of adverse drug events.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 26%
Student > Bachelor 8 16%
Student > Ph. D. Student 7 14%
Other 4 8%
Student > Doctoral Student 2 4%
Other 5 10%
Unknown 11 22%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 17 34%
Medicine and Dentistry 10 20%
Chemistry 2 4%
Social Sciences 2 4%
Nursing and Health Professions 1 2%
Other 4 8%
Unknown 14 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2015.
All research outputs
#15,520,469
of 25,382,440 outputs
Outputs from Farmacia Hospitalaria
#139
of 368 outputs
Outputs of similar age
#142,951
of 278,918 outputs
Outputs of similar age from Farmacia Hospitalaria
#2
of 8 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 368 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,918 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.