Title |
Uso de medicamentos fuera de ficha la técnica en oncohematología: resultado de una encuesta nacional
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Published in |
Farmacia Hospitalaria, September 2015
|
DOI | 10.7399/fh.2015.39.5.8979 |
Pubmed ID | |
Authors |
Eva González-Haba Peña, María José Agustín Ferrández, Irene Mangues Bafalluy, Nicolás Alfredo López, María Dolores Fraga Fuentes, Roberto Marín Gil, María José Martínez Bautista, Ana Clopés Estela |
Abstract |
identify by means of a survey the off-label treatments more often used in the oncohaematology area, as well as to know the established procedures and criteria used to authorise those treatments. a four-section survey was designed: 1) demographic data and hospital activity, 2) Off-label treatments protocol, 3) Approval criteria and 4) Off-label oncology treatments conducted during the last year. in 42.1% of the hospitals it's needed an authorisation before dispensing in more tan 80% of the treatments. The most influential factor in the approval-dispensation system is the available evidence. The consent of the hospital management with previous Pharmacy department's report was the most common authorisation procedure. 55.3% of the hospitals settled specific patient criteria to help the decision-making altogether with the available safety and efficacy data of the drug for the requested indication. In most centers a lower level of evidence is accepted if there are no therapeutic alternatives as well as in tumors of low prevalence. Most of the centers have not clearly established a criterion of effectiveness to consider a benefit as clinically relevant, nor the cost-effectiveness threshold for approving a FFT. there is a great variability in the off-label treatments use and also in the criteria used for its approval. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 1 | 6% |
Other | 3 | 18% |
Unknown | 7 | 41% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 12% |
Philosophy | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Chemistry | 1 | 6% |
Other | 0 | 0% |
Unknown | 9 | 53% |