Title |
Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia
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Published in |
Biomédica, March 2018
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DOI | 10.7705/biomedica.v38i0.3273 |
Pubmed ID | |
Authors |
Leandro Galvis, Ángel Y. Sánchez, Leonardo F. Jurado, Martha I. Murcia |
Abstract |
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections.We report the case of a 68-year-old man with Crohn's disease, who developed disseminated tuberculosis due to anti-TNF-α immunosuppressive therapy. The diagnosis was based on the histopathological findings and molecular biology assays.We discuss the clinical presentation and workup of this case, and we present a comparative analysis of tuberculosis cases associated with anti-TNF-α reported in Colombia during the last 10 years emphasizing on the diagnosis and treatment of latent tuberculosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 4 | 67% |
United Kingdom | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 14% |
Student > Postgraduate | 2 | 14% |
Student > Doctoral Student | 2 | 14% |
Unspecified | 1 | 7% |
Other | 1 | 7% |
Other | 0 | 0% |
Unknown | 6 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 36% |
Unspecified | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Business, Management and Accounting | 1 | 7% |
Unknown | 6 | 43% |