Title |
Large-scale analysis of the human and mouse transcriptomes
|
---|---|
Published in |
Proceedings of the National Academy of Sciences of the United States of America, March 2002
|
DOI | 10.1073/pnas.012025199 |
Pubmed ID | |
Authors |
Andrew I. Su, Michael P. Cooke, Keith A. Ching, Yaron Hakak, John R. Walker, Tim Wiltshire, Anthony P. Orth, Raquel G. Vega, Lisa M. Sapinoso, Aziz Moqrich, Ardem Patapoutian, Garret M. Hampton, Peter G. Schultz, John B. Hogenesch |
Abstract |
High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date, the vast majority of these experiments have focused on specific biological processes and perturbations. Here, we have generated and analyzed gene expression from a set of samples spanning a broad range of biological conditions. Specifically, we profiled gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines. Because these samples predominantly come from the normal physiological state in the human and mouse, this dataset represents a preliminary, but substantial, description of the normal mammalian transcriptome. We have used this dataset to illustrate methods of mining these data, and to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics. Finally, to allow the scientific community to use this resource, we have built a free and publicly accessible website (http://expression.gnf.org) that integrates data visualization and curation of current gene annotations. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 15 | 2% |
United Kingdom | 14 | 2% |
Germany | 6 | <1% |
Spain | 4 | <1% |
Netherlands | 3 | <1% |
Denmark | 2 | <1% |
Switzerland | 2 | <1% |
Canada | 2 | <1% |
Brazil | 1 | <1% |
Other | 12 | 2% |
Unknown | 555 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 168 | 27% |
Student > Ph. D. Student | 143 | 23% |
Professor > Associate Professor | 54 | 9% |
Student > Master | 51 | 8% |
Professor | 41 | 7% |
Other | 109 | 18% |
Unknown | 50 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 296 | 48% |
Biochemistry, Genetics and Molecular Biology | 90 | 15% |
Medicine and Dentistry | 51 | 8% |
Computer Science | 34 | 6% |
Engineering | 19 | 3% |
Other | 57 | 9% |
Unknown | 69 | 11% |