| Title |
Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women
|
|---|---|
| Published in |
BONE, May 2015
|
| DOI | 10.1016/j.bone.2015.05.010 |
| Pubmed ID | |
| Authors |
Andy K.O. Wong, Karen A. Beattie, Aakash Bhargava, Marco Cheung, Colin E. Webber, David R. Chettle, Alexandra Papaioannou, Jonathan D. Adachi, the Canadian Multicentre Osteoporosis Study Research Group |
| Abstract |
Conflicting evidence suggest that bone lead or blood lead may reduce areal bone mineral density (BMD). Little is known how lead at either compartment affects bone structure. This study examined postmenopausal women (N=38, mean age 76 ± 8, body mass index (BMI): 26.74 ± 4.26 kg/m(2)) within the Hamilton cohort of the Canadian Multicentre Osteoporosis Study (CaMos), measuring bone lead at 66% of the non-dominant leg and at the calcaneus using (109)Cadmium X-ray fluorescence. Volumetric BMD and structural parameters were obtained from peripheral quantitative computed tomography images (200 μm in-plane resolution, 2.3±0.5 mm slice thickness) of the same 66% site and of the distal 4% site of the tibia length. Blood lead was measured using atomic absorption spectrometry and blood-to-bone lead partition coefficients (PBB, log ratio) were computed. Multivariable linear regression examined each of bone lead at the 66% tibia, calcaneus, blood lead and PBB as related to each of volumetric BMD and structural parameters, adjusting for age and BMI, diabetes or antiresorptive therapy. Regression coefficients were reported along with 95% confidence intervals. Higher amounts of bone lead at the tibia were associated with thinner distal tibia cortices (-0.972(-1.882,-0.061) per 100 μg Pb/g of bone) and integral volumetric BMD (-3.05(-6.05,-0.05) per μg Pb/g of bone). A higher PBB was associated with larger trabecular separation (0.115(0.053,0.178)), lower trabecular volumetric BMD (-26.83(-50.37,-3.29)) and trabecular number (-0.08(-0.14,-0.02)), per 100 μg Pb/g of bone after adjusting for age and BMI, and remained significant while accounting for diabetes or use of antiresorptives. Total lead exposure activities related to bone lead at the calcaneus (8.29(0.11,16.48)) and remained significant after age and antiresorptives- adjustment. Lead accumulated in bone can have a mild insult on bone structure; but greater partitioning of lead in blood versus bone revealed more dramatic effects on both microstructure and volumetric BMD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 18% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Bachelor | 7 | 11% |
| Researcher | 5 | 8% |
| Student > Doctoral Student | 3 | 5% |
| Other | 12 | 18% |
| Unknown | 20 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 14% |
| Biochemistry, Genetics and Molecular Biology | 8 | 12% |
| Nursing and Health Professions | 4 | 6% |
| Chemistry | 4 | 6% |
| Agricultural and Biological Sciences | 4 | 6% |
| Other | 12 | 18% |
| Unknown | 25 | 38% |
Attention Score in Context
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#20,657,128
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#3,266
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#205,862
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Outputs of similar age from BONE
#63
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