| Title |
Build better bones with exercise (B3E pilot trial): results of a feasibility study of a multicenter randomized controlled trial of 12 months of home exercise in older women with vertebral fracture
|
|---|---|
| Published in |
Osteoporosis International, August 2018
|
| DOI | 10.1007/s00198-018-4652-0 |
| Pubmed ID | |
| Authors |
L.M. Giangregorio, J.C. Gibbs, J.A. Templeton, J.D. Adachi, M.C. Ashe, R.R. Bleakney, A.M. Cheung, K.D. Hill, D.L. Kendler, A. A. Khan, S. Kim, C. McArthur, N. Mittmann, A. Papaioannou, S. Prasad, S.C. Scherer, L. Thabane, J.D. Wark |
| Abstract |
We pilot-tested a trial of home exercise on individuals with osteoporosis and spine fracture. Our target enrollment was met, though it took longer than expected. Participants stayed in the study and completed the exercise program with no safety concerns. Future trials should expand the inclusion criteria and consider other changes. Osteoporotic fragility fractures create a substantial human and economic burden. There have been calls for a large randomized controlled trial examining the effect of exercise on fracture incidence. The B3E pilot trial was designed to evaluate the feasibility of a large trial examining the effects of home exercise on individuals at high risk of fracture. Community-dwelling women ≥ 65 years with radiographically confirmed vertebral compression fractures were recruited at seven sites in Canada and Australia. We randomized participants in a 1:1 ratio to a 12-month home exercise program or equal attention control group, both delivered by a physiotherapist (PT). Participants received six PT home visits in addition to monthly phone calls from the PT and a blinded research assistant. The primary feasibility outcomes of the study were recruitment rate (20 per site in 1 year), retention rate (75% completion), and intervention adherence rate (60% of weeks meeting exercise goals). Secondary outcomes included falls, fractures and adverse events. One hundred forty-one participants were recruited; an average of 20 per site, though most sites took longer than anticipated. Retention and adherence met the criteria for success: 92% of participants completed the study; average adherence was 66%. The intervention group did not differ significantly in the number of falls (IRR 0.97, 95% CI 0.58 to 1.63) or fragility fractures (OR 1.11, 95% CI 0.60 to 2.05) compared to the control group. There were 18 serious adverse events in the intervention group and 12 in the control group. An RCT of home exercise in women with vertebral fractures is feasible but recruitment was a challenge. Suggestions are made for the conduct of future trials. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 19 | 63% |
| Switzerland | 1 | 3% |
| Australia | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 8 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 60% |
| Scientists | 10 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 182 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 18% |
| Student > Bachelor | 22 | 12% |
| Student > Ph. D. Student | 15 | 8% |
| Student > Doctoral Student | 11 | 6% |
| Researcher | 10 | 5% |
| Other | 29 | 16% |
| Unknown | 62 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 20% |
| Nursing and Health Professions | 32 | 18% |
| Sports and Recreations | 11 | 6% |
| Agricultural and Biological Sciences | 4 | 2% |
| Psychology | 4 | 2% |
| Other | 21 | 12% |
| Unknown | 73 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2021.
All research outputs
#1,829,816
of 25,352,304 outputs
Outputs from Osteoporosis International
#285
of 3,857 outputs
Outputs of similar age
#36,535
of 337,565 outputs
Outputs of similar age from Osteoporosis International
#8
of 64 outputs
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