| Title |
Orbital/Periorbital Plexiform Neurofibromas in Children with Neurofibromatosis Type 1 Multidisciplinary Recommendations for Care
|
|---|---|
| Published in |
Ophthalmology, November 2016
|
| DOI | 10.1016/j.ophtha.2016.09.020 |
| Pubmed ID | |
| Authors |
Robert A. Avery, James A. Katowitz, Michael J. Fisher, Gena Heidary, Eva Dombi, Roger J. Packer, Brigitte C. Widemann, OPPN Working Group, Kelly A. Hutcheson, William P. Madigan, Robert Listernick, Grant T. Liu, Jerry E. Berland, Edmond J. FitzGibbon, Bruce R. Korf |
| Abstract |
Children and adults with neurofibromatosis type 1 (NF1), a common autosomal dominant condition, manifest a variety of ophthalmologic conditions. Plexiform neurofibromas (PNs) involving the eyelid, orbit, periorbital, and facial structures (orbital-periorbital plexiform neurofibroma [OPPN]) can result in significant visual loss in children. Equally important, OPPNs can cause significant alteration in physical appearance secondary to proptosis, ptosis, and facial disfigurement, leading to social embarrassment and decreased self-esteem. Although NF1 is a relatively common disease in which routine ophthalmologic examinations are required, no formal recommendations for clinical care of children with OPPNs exist. Although medical and surgical interventions have been reported, there are no agreed-on criteria for when OPPNs require therapy and which treatment produces the best outcome. Because a multidisciplinary team of specialists (oculofacial plastics, pediatric ophthalmology, neuro-ophthalmology, medical genetics, and neuro-oncology) direct management decisions, the absence of a uniform outcome measure that represents visual or aesthetic sequelae complicates the design of evidence-based studies and feasible clinical trials. In September 2013, a multidisciplinary task force, composed of pediatric practitioners from tertiary care centers experienced in caring for children with OPPN, was convened to address the lack of clinical care guidelines for children with OPPN. This consensus statement provides recommendations for ophthalmologic monitoring, outlines treatment indications and forthcoming biologic therapy, and discusses challenges to performing clinical trials in this complicated condition. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 111 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 12% |
| Student > Master | 10 | 9% |
| Student > Doctoral Student | 10 | 9% |
| Student > Ph. D. Student | 9 | 8% |
| Other | 8 | 7% |
| Other | 25 | 22% |
| Unknown | 37 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 46% |
| Nursing and Health Professions | 7 | 6% |
| Psychology | 4 | 4% |
| Social Sciences | 3 | 3% |
| Economics, Econometrics and Finance | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 38 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2020.
All research outputs
#2,893,389
of 25,837,817 outputs
Outputs from Ophthalmology
#911
of 6,879 outputs
Outputs of similar age
#47,322
of 319,901 outputs
Outputs of similar age from Ophthalmology
#18
of 101 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,879 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.