| Title |
Relationships Between Selected Gene Polymorphisms and Blood Pressure Sensitivity to Weight Loss in Elderly Persons With Hypertension
|
|---|---|
| Published in |
Hypertension, February 2013
|
| DOI | 10.1161/hypertensionaha.111.00712 |
| Pubmed ID | |
| Authors |
William J. Kostis, Javier Cabrera, W. Craig Hooper, Paul K. Whelton, Mark A. Espeland, Nora M. Cosgrove, Jerry Q. Cheng, Yingzi Deng, Christine De Staerck, Meredith Pyle, Nisa Maruthur, Ingrid Reyes, Cheryl A.M. Anderson, Jie Liu, John B. Kostis |
| Abstract |
Salt sensitivity, the heterogeneity in the response of blood pressure (BP) to alterations in sodium intake, has been studied extensively, whereas weight sensitivity, the heterogeneity in BP response to weight change, has received scant attention. We examined the relationship of 21 gene polymorphisms previously found to be associated with hypertension, diabetes mellitus, or obesity, with weight sensitivity in the Trial of Nonpharmacologic Interventions in the Elderly, where participants with hypertension were randomized to receive intensive dietary intervention of sodium reduction, weight loss, both, or attention control, whereas pharmacological therapy was kept constant. After correcting for multiplicity, we identified significant associations of 3 polymorphisms with weight sensitivity of systolic BP (rs4646994, rs2820037, and rs1800629) and 3 polymorphisms for diastolic BP (rs4646994, rs2820037, and rs5744292). A recursive partitioning algorithm selected the combination of rs4646994, rs1800629, rs1982073, and rs1800896 as the set associated with the highest weight sensitivity. Polymorphisms related to hypertension, obesity, and diabetes mellitus are associated with weight sensitivity of BP. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Unknown | 80 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 15% |
| Student > Bachelor | 12 | 15% |
| Researcher | 11 | 14% |
| Student > Ph. D. Student | 10 | 12% |
| Student > Doctoral Student | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 19 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 22% |
| Agricultural and Biological Sciences | 11 | 14% |
| Nursing and Health Professions | 6 | 7% |
| Computer Science | 4 | 5% |
| Sports and Recreations | 3 | 4% |
| Other | 13 | 16% |
| Unknown | 26 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2023.
All research outputs
#14,840,825
of 25,744,802 outputs
Outputs from Hypertension
#4,772
of 7,207 outputs
Outputs of similar age
#111,548
of 206,343 outputs
Outputs of similar age from Hypertension
#27
of 104 outputs
Altmetric has tracked 25,744,802 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,207 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,343 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.