| Title |
Telomere Length and Breast Cancer Prognosis: A Systematic Review
|
|---|---|
| Published in |
Cancer Epidemiology, Biomarkers & Prevention, January 2017
|
| DOI | 10.1158/1055-9965.epi-16-0343 |
| Pubmed ID | |
| Authors |
Kaoutar Ennour-Idrissi, Elizabeth Maunsell, Caroline Diorio |
| Abstract |
Telomeres ensure genome integrity during replication. Loss of telomeric function leads to cell immortalization and accumulation of genetic alterations. The association of telomere length (TL) with breast cancer prognosis is examined through a systematic review. Electronic databases (MEDLINE, EMBASE, CENTRAL), from inception to December 2015, and relevant reviews were searched. Studies that evaluated TL (blood and/or tumor) in association with breast cancer survival or prognostic factor, were included. Thirty-six studies met inclusion criteria. Overall risk of bias was critical. Eight studies reported survival outcomes. Overall, there was a trend toward an association of longer telomeres with better outcomes (tumor, not blood). Of the 33 studies reporting associations with prognostic factors, nine adjusted for potential confounders. Among the latter, shorter telomeres were associated with older age (blood, not tumor), higher local recurrence rates (normal tissue), higher tumor grade (tumor) and lower physical activity (blood), which were reported in one study each. TL was not associated with molecular subtype (blood, one study), family history (tumor, one study), and chemotherapy (blood, three out of four studies), stress reduction interventions (blood, two out of two studies). Although major methodological differences preclude from drawing conclusive results, TL could be a valuable breast cancer prognostic marker. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 1% |
| Unknown | 88 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 16% |
| Student > Ph. D. Student | 13 | 15% |
| Student > Bachelor | 12 | 13% |
| Researcher | 10 | 11% |
| Student > Postgraduate | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 20 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 22% |
| Biochemistry, Genetics and Molecular Biology | 16 | 18% |
| Agricultural and Biological Sciences | 6 | 7% |
| Sports and Recreations | 5 | 6% |
| Psychology | 3 | 3% |
| Other | 11 | 12% |
| Unknown | 28 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2017.
All research outputs
#20,660,571
of 25,377,790 outputs
Outputs from Cancer Epidemiology, Biomarkers & Prevention
#3,851
of 4,849 outputs
Outputs of similar age
#320,296
of 421,814 outputs
Outputs of similar age from Cancer Epidemiology, Biomarkers & Prevention
#56
of 79 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,849 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,814 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.