| Title |
Molecular Biomarkers for the Evaluation of Colorectal Cancer Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology
|
|---|---|
| Published in |
The Journal of Molecular Diagnostics, February 2017
|
| DOI | 10.1016/j.jmoldx.2016.11.001 |
| Pubmed ID | |
| Authors |
Antonia R. Sepulveda, Stanley R. Hamilton, Carmen J. Allegra, Wayne Grody, Allison M. Cushman-Vokoun, William K. Funkhouser, Scott E. Kopetz, Christopher Lieu, Noralane M. Lindor, Bruce D. Minsky, Federico A. Monzon, Daniel J. Sargent, Veena M. Singh, Joseph Willis, Jennifer Clark, Carol Colasacco, R. Bryan Rumble, Robyn Temple-Smolkin, Christina B. Ventura, Jan A. Nowak |
| Abstract |
To develop evidence-based guideline recommendations through a systematic review of the literature to establish standard molecular biomarker testing of colorectal cancer (CRC) tissues to guide epidermal growth factor receptor (EGFR) therapies and conventional chemotherapy regimens. The American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology convened an expert panel to develop an evidence-based guideline to establish standard molecular biomarker testing and guide therapies for patients with CRC. A comprehensive literature search that included more than 4,000 articles was conducted. Twenty-one guideline statements were established. Evidence supports mutational testing for EGFR signaling pathway genes, since they provide clinically actionable information as negative predictors of benefit to anti-EGFR monoclonal antibody therapies for targeted therapy of CRC. Mutations in several of the biomarkers have clear prognostic value. Laboratory approaches to operationalize CRC molecular testing are presented. Key Words: Molecular diagnostics; Gastrointestinal; Histology; Genetics; Oncology. |
X Demographics
The data shown below were collected from the profiles of 100 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 33 | 33% |
| Spain | 6 | 6% |
| Brazil | 4 | 4% |
| United Kingdom | 3 | 3% |
| Australia | 3 | 3% |
| Canada | 3 | 3% |
| Mexico | 2 | 2% |
| Turkey | 2 | 2% |
| Ecuador | 2 | 2% |
| Other | 11 | 11% |
| Unknown | 31 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 53 | 53% |
| Scientists | 24 | 24% |
| Practitioners (doctors, other healthcare professionals) | 20 | 20% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 133 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 14% |
| Other | 14 | 11% |
| Student > Master | 14 | 11% |
| Student > Bachelor | 12 | 9% |
| Student > Postgraduate | 12 | 9% |
| Other | 26 | 20% |
| Unknown | 36 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 31% |
| Biochemistry, Genetics and Molecular Biology | 24 | 18% |
| Agricultural and Biological Sciences | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Nursing and Health Professions | 4 | 3% |
| Other | 13 | 10% |
| Unknown | 39 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 527. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2020.
All research outputs
#47,450
of 25,420,980 outputs
Outputs from The Journal of Molecular Diagnostics
#3
of 1,306 outputs
Outputs of similar age
#1,051
of 424,970 outputs
Outputs of similar age from The Journal of Molecular Diagnostics
#1
of 17 outputs
Altmetric has tracked 25,420,980 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,306 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,970 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.