| Title |
Genome‐wide analysis identifies an african‐specific variant in SEMA4D associated with body mass index
|
|---|---|
| Published in |
Obesity, March 2017
|
| DOI | 10.1002/oby.21804 |
| Pubmed ID | |
| Authors |
Guanjie Chen, Ayo P. Doumatey, Jie Zhou, Lin Lei, Amy R. Bentley, Fasil Tekola-Ayele, Sally N. Adebamowo, Jennifer L. Baker, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim‐Boateng, Albert Amoah, Clement Adebamowo, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Daniel Shriner, Adebowale A. Adeyemo, Charles N. Rotimi |
| Abstract |
The prevalence of obesity varies between ethnic groups. No genome-wide association study (GWAS) for body mass index (BMI) has been conducted in continental Africans. We performed a GWAS for BMI in 1,570 West Africans (WA). Replication was conducted in independent samples of WA (n = 1,411) and African Americans (AA) (n = 9,020). We identified a novel genome-wide significant African-specific locus for BMI (SEMA4D, rs80068415; minor allele frequency = 0.008, P = 2.10 × 10(-8) ). This finding was replicated in independent samples of WA (P = 0.013) and AA (P = 0.017). Individuals with obesity had higher serum SEMA4D levels compared to those without obesity (P < 0.0001), and elevated levels of serum SEMA4D were associated with increased obesity risk (OR = 4.2, P < 1 × 10(-4) ). The prevalence of obesity was higher in individuals with the CT versus TT genotypes (55.6% vs. 22.9%). A novel variant in SEMA4D was significantly associated with BMI. Carriers of the C allele were 4.6 BMI units heavier than carriers of the T allele (P = 0.0007). This variant is monomorphic in Europeans and Asians, highlighting the importance of studying diverse populations. While there is evidence for the involvement of SEMA4D in inflammatory processes, this study is the first to implicate SEMA4D in obesity pathophysiology. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 29% |
| United Kingdom | 5 | 21% |
| Djibouti | 1 | 4% |
| Brazil | 1 | 4% |
| France | 1 | 4% |
| Unknown | 9 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 54% |
| Scientists | 7 | 29% |
| Practitioners (doctors, other healthcare professionals) | 3 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 18% |
| Student > Bachelor | 8 | 16% |
| Student > Doctoral Student | 4 | 8% |
| Student > Postgraduate | 4 | 8% |
| Student > Ph. D. Student | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 14 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 14% |
| Agricultural and Biological Sciences | 6 | 12% |
| Neuroscience | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 16 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 196. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2018.
All research outputs
#190,443
of 24,458,924 outputs
Outputs from Obesity
#180
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Outputs of similar age
#4,232
of 312,948 outputs
Outputs of similar age from Obesity
#5
of 83 outputs
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