| Title |
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
|
|---|---|
| Published in |
European Heart Journal, April 2017
|
| DOI | 10.1093/eurheartj/ehx213 |
| Pubmed ID | |
| Authors |
Ji-Young Lee, Tae-Hoon Kim, Pil-Sung Yang, Hong Euy Lim, Eue-Keun Choi, Jaemin Shim, Eunsoon Shin, Jae-Sun Uhm, Jin-Seok Kim, Boyoung Joung, Seil Oh, Moon-Hyoung Lee, Young-Hoon Kim, Hui-Nam Pak |
| Abstract |
Some genetic susceptibility loci for atrial fibrillation (AF) identified by genome-wide association studies (GWAS) in a European database showed ethnic differences in the Asian population. We explored novel AF susceptibility variants for patients with early-onset AF (≤60 years old) among Korean patients who underwent AF catheter ablation. A genome-wide association study (GWAS) was conducted with 672 cases (≤60 years old, Yonsei AF Ablation cohort) and 3700 controls (Korea Genome Epidemiology Study). Association analysis was performed under an additive model of logistic regression, and replication study was conducted with 200 independent cases of Korean AF Network and 1812 controls. Five previously proven genetic loci (1q24/PRRX1, 4q25/PITX2, 10q24/NEURL, 12q24/TBX5, and 16q22/ZFHX3) were validated. Two novel genetic loci associated with early-onset AF were found on chromosomes 1q32.1/PPFIA4 (rs11579055, P = 6.84 × 10-10) and 4q34.1/HAND2 (rs8180252, P = 1.49 × 10-11) and replicated in an additional independent sample of the Korean AF Network. The identified loci implicate candidate genes that encode proteins related to cell-to-cell connection, hypoxic status, or long non-coding RNA. Two novel genetic loci for early-onset AF were identified in Korean patients who underwent catheter ablation. One of the novel susceptibility loci on chromosome 4 has strong associations with previously proven gene in a European ancestry database. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| Spain | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 24% |
| Researcher | 8 | 15% |
| Other | 7 | 13% |
| Student > Doctoral Student | 6 | 11% |
| Student > Bachelor | 4 | 7% |
| Other | 10 | 18% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 38% |
| Biochemistry, Genetics and Molecular Biology | 13 | 24% |
| Agricultural and Biological Sciences | 4 | 7% |
| Computer Science | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2017.
All research outputs
#7,991,243
of 25,450,869 outputs
Outputs from European Heart Journal
#5,865
of 11,078 outputs
Outputs of similar age
#116,993
of 323,608 outputs
Outputs of similar age from European Heart Journal
#72
of 154 outputs
Altmetric has tracked 25,450,869 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 11,078 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.6. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.