| Title |
Recommendations for Surveillance for Children with Leukemia-Predisposing Conditions
|
|---|---|
| Published in |
Clinical Cancer Research, May 2017
|
| DOI | 10.1158/1078-0432.ccr-17-0428 |
| Pubmed ID | |
| Authors |
Christopher C. Porter, Todd E. Druley, Ayelet Erez, Roland P. Kuiper, Kenan Onel, Joshua D. Schiffman, Kami Wolfe Schneider, Sarah R. Scollon, Hamish S. Scott, Louise C. Strong, Michael F. Walsh, Kim E. Nichols |
| Abstract |
Leukemia, the most common childhood cancer, has long been recognized to occasionally run in families. The first clues about the genetic mechanisms underlying familial leukemia emerged in 1990 when Li-Fraumeni syndrome was linked to TP53 mutations. Since this discovery, many other genes associated with hereditary predisposition to leukemia have been identified. Although several of these disorders also predispose individuals to solid tumors, certain conditions exist in which individuals are specifically at increased risk to develop myelodysplastic syndrome (MDS) and/or acute leukemia. The increasing identification of affected individuals and families has raised questions around the efficacy, timing, and optimal methods of surveillance. As part of the AACR Childhood Cancer Predisposition Workshop, an expert panel met to review the spectrum of leukemia-predisposing conditions, with the aim to develop consensus recommendations for surveillance for pediatric patients. The panel recognized that for several conditions, routine monitoring with complete blood counts and bone marrow evaluations is essential to identify disease evolution and enable early intervention with allogeneic hematopoietic stem cell transplantation. However, for others, less intensive surveillance may be considered. Because few reports describing the efficacy of surveillance exist, the recommendations derived by this panel are based on opinion, and local experience and will need to be revised over time. The development of registries and clinical trials is urgently needed to enhance understanding of the natural history of the leukemia-predisposing conditions, such that these surveillance recommendations can be optimized to further enhance long-term outcomes. Clin Cancer Res; 23(11); e14-e22. ©2017 AACRSee all articles in the online-only CCR Pediatric Oncology Series. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Belgium | 1 | 13% |
| Saudi Arabia | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Science communicators (journalists, bloggers, editors) | 2 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Unknown | 115 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 19 | 16% |
| Researcher | 15 | 13% |
| Student > Ph. D. Student | 10 | 9% |
| Student > Master | 10 | 9% |
| Student > Bachelor | 8 | 7% |
| Other | 30 | 26% |
| Unknown | 24 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 55 | 47% |
| Biochemistry, Genetics and Molecular Biology | 14 | 12% |
| Nursing and Health Professions | 6 | 5% |
| Agricultural and Biological Sciences | 3 | 3% |
| Chemistry | 3 | 3% |
| Other | 6 | 5% |
| Unknown | 29 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2019.
All research outputs
#2,049,982
of 23,573,233 outputs
Outputs from Clinical Cancer Research
#1,665
of 12,779 outputs
Outputs of similar age
#40,599
of 317,224 outputs
Outputs of similar age from Clinical Cancer Research
#44
of 218 outputs
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So far Altmetric has tracked 12,779 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has done well, scoring higher than 86% of its peers.
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We're also able to compare this research output to 218 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.