| Title |
Digitizing Medicines for Remote Capture of Oral Medication Adherence Using Co‐encapsulation
|
|---|---|
| Published in |
Clinical Pharmacology & Therapeutics, September 2017
|
| DOI | 10.1002/cpt.760 |
| Pubmed ID | |
| Authors |
SH Browne, C Peloquin, F Santillo, R Haubrich, L Muttera, K Moser, GM Savage, CA Benson, TF Blaschke |
| Abstract |
High-resolution measurement of medication adherence is essential to personalized drug therapy . An FDA-cleared device, using an edible ingestion sensor (IS), external wearable patch and paired mobile device, can detect and record ingestion events. Oral medications must be combined with an IS to generate precise 'digitized-medication' ingestion records. We developed a GMP-protocol to repackage oral medications with the IS within certified Capsugel® capsules, termed co-encapsulation (CoE). A randomized bioequivalence study of CoE-IS-Rifamate (Isoniazid/Rifampin 150/300mg) versus native-Rifamate was conducted in 12 patients with active Mycobacterium Tuberculosis (MTB) and demonstrated bioequivalence using the population method ratio test (95% CI). Subsequently, CoE-IS-medications across all bio-pharmaceutical classes underwent in-vitro dissolution testing utilizing USP and FDA guidelines. CoE-IS-medications tested met USP dissolution specifications and were equivalent to their native formulations. Co-encapsulation combines oral medications with the IS without altering the quality of the native formulation, generating 'digitize' medications for remote capture of dosing histories. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 12% |
| Other | 12 | 10% |
| Student > Bachelor | 10 | 8% |
| Researcher | 8 | 7% |
| Student > Ph. D. Student | 6 | 5% |
| Other | 20 | 17% |
| Unknown | 50 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 10% |
| Nursing and Health Professions | 12 | 10% |
| Social Sciences | 4 | 3% |
| Unspecified | 4 | 3% |
| Other | 12 | 10% |
| Unknown | 52 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2019.
All research outputs
#8,108,185
of 24,484,013 outputs
Outputs from Clinical Pharmacology & Therapeutics
#1,747
of 4,371 outputs
Outputs of similar age
#122,357
of 322,418 outputs
Outputs of similar age from Clinical Pharmacology & Therapeutics
#19
of 46 outputs
Altmetric has tracked 24,484,013 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 4,371 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,418 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.