| Title |
Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits
|
|---|---|
| Published in |
Nature Genetics, June 2017
|
| DOI | 10.1038/ng.3888 |
| Pubmed ID | |
| Authors |
Anke R Hammerschlag, Sven Stringer, Christiaan A de Leeuw, Suzanne Sniekers, Erdogan Taskesen, Kyoko Watanabe, Tessa F Blanken, Kim Dekker, Bart H W te Lindert, Rick Wassing, Ingileif Jonsdottir, Gudmar Thorleifsson, Hreinn Stefansson, Thorarinn Gislason, Klaus Berger, Barbara Schormair, Juergen Wellmann, Juliane Winkelmann, Kari Stefansson, Konrad Oexle, Eus J W Van Someren, Danielle Posthuma |
| Abstract |
Persistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and a genome-wide gene-based association study (GWGAS) in 113,006 individuals. We identify three loci and seven genes associated with insomnia complaints, with the associations for one locus and five genes supported by joint analysis with an independent sample (n = 7,565). Our top association (MEIS1, P < 5 × 10(-8)) has previously been implicated in restless legs syndrome (RLS). Additional analyses favor the hypothesis that MEIS1 exhibits pleiotropy for insomnia and RLS and show that the observed association with insomnia complaints cannot be explained only by the presence of an RLS subgroup within the cases. Sex-specific analyses suggest that there are different genetic architectures between the sexes in addition to shared genetic factors. We show substantial positive genetic correlation of insomnia complaints with internalizing personality traits and metabolic traits and negative correlation with subjective well-being and educational attainment. These findings provide new insight into the genetic architecture of insomnia. |
X Demographics
The data shown below were collected from the profiles of 152 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 29 | 19% |
| United Kingdom | 25 | 16% |
| Saudi Arabia | 8 | 5% |
| Netherlands | 6 | 4% |
| Australia | 4 | 3% |
| France | 3 | 2% |
| Canada | 3 | 2% |
| Germany | 2 | 1% |
| Switzerland | 2 | 1% |
| Other | 11 | 7% |
| Unknown | 59 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 83 | 55% |
| Scientists | 52 | 34% |
| Practitioners (doctors, other healthcare professionals) | 13 | 9% |
| Science communicators (journalists, bloggers, editors) | 4 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 332 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Unknown | 331 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 67 | 20% |
| Researcher | 61 | 18% |
| Student > Master | 35 | 11% |
| Student > Bachelor | 25 | 8% |
| Other | 16 | 5% |
| Other | 56 | 17% |
| Unknown | 72 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 16% |
| Agricultural and Biological Sciences | 44 | 13% |
| Biochemistry, Genetics and Molecular Biology | 40 | 12% |
| Psychology | 35 | 11% |
| Neuroscience | 34 | 10% |
| Other | 36 | 11% |
| Unknown | 89 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 737. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2023.
All research outputs
#27,673
of 25,779,988 outputs
Outputs from Nature Genetics
#41
of 7,623 outputs
Outputs of similar age
#498
of 332,939 outputs
Outputs of similar age from Nature Genetics
#2
of 74 outputs
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