| Title |
Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts
|
|---|---|
| Published in |
Heart Rhythm, June 2017
|
| DOI | 10.1016/j.hrthm.2017.06.018 |
| Pubmed ID | |
| Authors |
Kathleen F Kerr, Christy L Avery, Henry J Lin, Laura M Raffield, Qian S Zhang, Brian L Browning, Sharon R Browning, Matthew P Conomos, Stephanie M Gogarten, Cathy C Laurie, Tamar Sofer, Timothy A Thornton, Chancellor Hohensee, Rebecca D Jackson, Charles Kooperberg, Yun Li, Raúl Méndez-Giráldez, Marco V Perez, Ulrike Peters, Alexander P Reiner, Zhu-Ming Zhang, Jie Yao, Nona Sotoodehnia, Kent D Taylor, Xiuqing Guo, Leslie A Lange, Elsayed Z Soliman, James G Wilson, Jerome I Rotter, Susan R Heckbert, Deepti Jain, Eric A Whitsel |
| Abstract |
Although time-domain measures of heart rate variability (HRV) are used to estimate cardiac autonomic tone and disease risk in multi-ethnic populations, the genetic epidemiology of HRV in Hispanics/Latinos has not been characterized. Conduct a genome-wide association study (GWAS) of heart rate (HR) and its variability in the Hispanic Community Health Study / Study of Latinos, Multi-Ethnic Study of Atherosclerosis, and Women's Health Initiative Hispanic SNP-Health Association Resource project (n=13,767). We estimated HR (beats/min), the standard deviation of normal-to-normal inter-beat intervals (SDNN, ms), and the root mean squared difference in successive, normal-to-normal inter-beat intervals (RMSSD, ms) from resting, standard twelve-lead electrocardiograms. We estimated associations between each phenotype and 17 million genotyped or imputed single nucleotide polymorphisms (SNPs), accounting for relatedness and adjusting for age, sex, study site, and ancestry. Cohort-specific estimates were combined using fixed-effects, inverse-variance meta-analysis. We investigated replication for select SNPs exceeding genome-wide (P<5x10(-8)) or suggestive (P<10(-6)) significance thresholds. Two genome-wide significant SNPs replicated in a European ancestry cohort, one for RMSSD (rs4963772; chromosome 12) and another for SDNN (rs12982903; chromosome 19). A suggestive SNP for HR (rs236352; chromosome 6) replicated in an African American cohort. Functional annotation of replicated SNPs in cardiac and neuronal tissues identified potentially causal variants and mechanisms. This first GWAS of HRV and HR in Hispanics/Latinos underscores the potential for even modestly-sized samples of non-European ancestry to inform the genetic epidemiology of complex traits. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| Switzerland | 2 | 29% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Scientists | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 18% |
| Researcher | 8 | 16% |
| Student > Doctoral Student | 4 | 8% |
| Professor | 3 | 6% |
| Student > Postgraduate | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 15 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 31% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Nursing and Health Professions | 2 | 4% |
| Engineering | 2 | 4% |
| Neuroscience | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 17 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2017.
All research outputs
#7,962,193
of 25,382,440 outputs
Outputs from Heart Rhythm
#2,102
of 4,509 outputs
Outputs of similar age
#118,341
of 331,653 outputs
Outputs of similar age from Heart Rhythm
#59
of 113 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,509 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has gotten more attention than average, scoring higher than 52% of its peers.
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