| Title |
Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD
|
|---|---|
| Published in |
European Neuropsychopharmacology, July 2017
|
| DOI | 10.1016/j.euroneuro.2017.03.011 |
| Pubmed ID | |
| Authors |
W. Guo, J.F. Samuels, Y. Wang, H. Cao, M. Ritter, P.S. Nestadt, J. Krasnow, B.D. Greenberg, A.J. Fyer, J.T. McCracken, D.A. Geller, D.L. Murphy, J.A. Knowles, M.A. Grados, M.A. Riddle, S.A. Rasmussen, N.C. McLaughlin, E.L. Nurmi, K.D. Askland, B.A. Cullen, J. Piacentini, D.L. Pauls, O.J. Bienvenu, S.E. Stewart, F.S. Goes, B. Maher, A.E. Pulver, D. Valle, M. Mattheisen, J. Qian, G. Nestadt, Y.Y. Shugart |
| Abstract |
Obsessive-compulsive disorder (OCD) and Autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders that conceivably share genetic risk factors. However, the underlying genetic determinants remain largely unknown. In this work, the authors describe a combined genome-wide association study (GWAS) of ASD and OCD. The OCD dataset includes 2998 individuals in nuclear families. The ASD dataset includes 6898 individuals in case-parents trios. GWAS summary statistics were examined for potential enrichment of functional variants associated with gene expression levels in brain regions. The top ranked SNP is rs4785741 (chromosome 16) with P value=6.9×10(-7) in our re-analysis. Polygenic risk score analyses were conducted to investigate the genetic relationship within and across the two disorders. These analyses identified a significant polygenic component of ASD, predicting 0.11% of the phenotypic variance in an independent OCD data set. In addition, we examined the genomic architecture of ASD and OCD by estimating heritability on different chromosomes and different allele frequencies, analyzing genome-wide common variant data by using the Genome-wide Complex Trait Analysis (GCTA) program. The estimated global heritability of OCD is 0.427 (se=0.093) and 0.174 (se=0.053) for ASD in these imputed data. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 13% |
| Bosnia and Herzegovina | 1 | 13% |
| United Kingdom | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 148 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 16% |
| Student > Master | 20 | 14% |
| Researcher | 15 | 10% |
| Student > Bachelor | 14 | 9% |
| Other | 9 | 6% |
| Other | 21 | 14% |
| Unknown | 46 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 15% |
| Psychology | 20 | 14% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Neuroscience | 14 | 9% |
| Nursing and Health Professions | 7 | 5% |
| Other | 17 | 11% |
| Unknown | 52 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2022.
All research outputs
#6,845,556
of 25,654,806 outputs
Outputs from European Neuropsychopharmacology
#655
of 2,584 outputs
Outputs of similar age
#99,599
of 327,569 outputs
Outputs of similar age from European Neuropsychopharmacology
#11
of 54 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,584 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has gotten more attention than average, scoring higher than 74% of its peers.
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