| Title |
Greater Cognitive Deficits with Sleep-disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer Disease. The Multi-Ethnic Study of Atherosclerosis
|
|---|---|
| Published in |
Annals of the American Thoracic Society, July 2017
|
| DOI | 10.1513/annalsats.201701-052oc |
| Pubmed ID | |
| Authors |
Dayna A Johnson, Jacqueline Lane, Rui Wang, Michelle Reid, Ina Djonlagic, Annette L Fitzpatrick, Stephen R Rapp, Luenda E Charles, Ruth O'Hara, Richa Saxena, Susan Redline |
| Abstract |
There are conflicting findings regarding the link between sleep apnea and cognitive dysfunction. Investigate associations between indicators of sleep-disordered breathing (SDB) and cognitive function in the Multi-Ethnic Study of Atherosclerosis and assess effect modification by the apolipoprotein ε-4 (APOE-ε4) allele. A diverse population (N=1,752) underwent Type 2 in-home polysomnography, which included measurement of % sleep time <90% oxyhemoglobin saturation (%Sat<90%) and apnea-hypopnea index (AHI). Epworth Sleepiness Scale score (ESS) and sleep apnea syndrome (SAS; AHI > 5 and ESS> 10) were also analyzed. Cognitive outcomes included the Cognitive Abilities Screening Instrument (CASI); Digit Symbol Coding Test (DSC); and Digit Span Tests (DST) Forward and Backward. Participants were 45.4% male, age 68.1(standard deviation: 9.1) years with a median AHI=9.0 and mean ESS=6.0. Approximately, 9.7% had SAS and 26.8% had at least one copy of the APOε4 allele. In adjusted analyses, a one standard deviation increase in %Sat<90% and ESS score were associated with a poorer attention and memory assessed by the DST Forward score (β=-0.12 (standard error: 0.06) and β=-0.13 (0.06), respectively; P<0.05). SAS and higher ESS scores were also associated with poorer attention and processing speed as measured by the DSC, β=-0.69 (0.35) and β=-1.42 (0.35), respectively (P<0.05). The presence of APOE-ε4 allele modified the associations of %Sat<90% with DST forward and of ESS with DSCT, Pinteraction<0.05. Overnight hypoxemia and sleepiness were associated with cognition. The average effect estimates were small, similar to effects estimated for several other individual dementia risk factors. Associations were strongest in APOE-ε4 risk allele carriers. Our results: 1) suggest that SDB be considered among a group of modifiable dementia risk factors; and 2) highlight the potential vulnerability of APOE-ε4 risk allele carriers with SDB. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 44% |
| Spain | 2 | 13% |
| Netherlands | 1 | 6% |
| Portugal | 1 | 6% |
| Brazil | 1 | 6% |
| Israel | 1 | 6% |
| Unknown | 3 | 19% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 63% |
| Scientists | 3 | 19% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 99 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 16% |
| Researcher | 12 | 12% |
| Student > Bachelor | 12 | 12% |
| Student > Ph. D. Student | 7 | 7% |
| Student > Doctoral Student | 5 | 5% |
| Other | 18 | 18% |
| Unknown | 29 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 16% |
| Psychology | 16 | 16% |
| Neuroscience | 9 | 9% |
| Nursing and Health Professions | 5 | 5% |
| Social Sciences | 3 | 3% |
| Other | 14 | 14% |
| Unknown | 36 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 204. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#192,673
of 25,382,440 outputs
Outputs from Annals of the American Thoracic Society
#43
of 3,599 outputs
Outputs of similar age
#4,059
of 324,641 outputs
Outputs of similar age from Annals of the American Thoracic Society
#2
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