Title |
Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.
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Published in |
Journal of the National Comprehensive Cancer Network (JNCCN), August 2016
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DOI | 10.6004/jnccn.2016.0108 |
Pubmed ID | |
Authors |
Dawn Provenzale, Samir Gupta, Dennis J Ahnen, Travis Bray, Jamie A Cannon, Gregory Cooper, Donald S David, Dayna S Early, Deborah Erwin, James M Ford, Francis M Giardiello, William Grady, Amy L Halverson, Stanley R Hamilton, Heather Hampel, Mohammad K Ismail, Jason B Klapman, David W Larson, Audrey J Lazenby, Patrick M Lynch, Robert J Mayer, Reid M Ness, Scott E Regenbogen, Niloy Jewel Samadder, Moshe Shike, Gideon Steinbach, David Weinberg, Mary Dwyer, Susan Darlow |
Abstract |
This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
Unknown | 76 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 16% |
Other | 11 | 14% |
Student > Ph. D. Student | 9 | 12% |
Student > Bachelor | 6 | 8% |
Student > Postgraduate | 6 | 8% |
Other | 15 | 19% |
Unknown | 18 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 34 | 44% |
Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Agricultural and Biological Sciences | 5 | 6% |
Nursing and Health Professions | 3 | 4% |
Immunology and Microbiology | 1 | 1% |
Other | 3 | 4% |
Unknown | 21 | 27% |