| Title |
Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study
|
|---|---|
| Published in |
Gynecologic Oncology, September 2017
|
| DOI | 10.1016/j.ygyno.2017.08.024 |
| Pubmed ID | |
| Authors |
Kathleen N. Moore, David Tritchler, Kenneth M. Kaufman, Heather Lankes, Michael C.J. Quinn, on behalf of the Ovarian Cancer Association Consortium, Linda Van Le, Andrew Berchuck, Floor J. Backes, Krishnansu S. Tewari, Roger B. Lee, Joshua P. Kesterson, Robert M. Wenham, Deborah K. Armstrong, Thomas C. Krivak, Michael A. Bookman, Michael J. Birrer |
| Abstract |
This study evaluated single nucleotide polymorphisms (SNPs) associated with progression free (PFS) and overall survival (OS) in patients with advanced stage serous EOC. Patients enrolled in GOG-172 and 182 who provided specimens for translational research and consent were included. Germline DNA was evaluated with the Illumina's HumanOMNI1-Quad beadchips and scanned using Illumina's iScan optical imaging system. SNPs with allele frequency>0.05 and genotyping rate>0.98 were included. Analysis of SNPs for PFS and OS was done using Cox regression. Statistical significance was determined using Bonferroni corrected p-values with genomic control adjustment. The initial GWAS analysis included 1,124,677 markers in 396 patients. To obtain the final data set, quality control checks were performed and limited to serous tumors and self-identified Caucasian race. In total 636,555 SNPs and 289 patients passed all the filters. The pre-specified statistical level of significance was 7.855e(-08). No SNPs met this criteria for PFS or OS, however, two SNPs were close to significance (rs10899426 p-2.144e(-)(08)) (rs6256 p-9.774e(-07)) for PFS and 2 different SNPs were identified (rs295315 p-7.536e(-)(07); rs17693104 p-7.734e(-)(07)) which were close to significance for OS. Using the pre-specified level of significance of 1×10(-08), we did not identify any SNPs of statistical significance for OS or PFS, however several were close. The SNP's identified in this GWAS study will require validation and these preliminary findings may lead to identification of novel pathways and biomarkers. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 25% |
| Researcher | 4 | 20% |
| Student > Ph. D. Student | 2 | 10% |
| Professor > Associate Professor | 2 | 10% |
| Professor | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 5 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 25% |
| Biochemistry, Genetics and Molecular Biology | 3 | 15% |
| Agricultural and Biological Sciences | 2 | 10% |
| Nursing and Health Professions | 1 | 5% |
| Computer Science | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 7 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2017.
All research outputs
#17,302,400
of 25,394,764 outputs
Outputs from Gynecologic Oncology
#3,828
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Outputs of similar age
#208,734
of 325,322 outputs
Outputs of similar age from Gynecologic Oncology
#34
of 51 outputs
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