| Title |
Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus
|
|---|---|
| Published in |
Journal of Diabetes Research, September 2017
|
| DOI | 10.1155/2017/9631435 |
| Pubmed ID | |
| Authors |
Muhammad U. Sohail, Asmaa Althani, Haseeb Anwar, Roberto Rizzi, Hany E. Marei |
| Abstract |
The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 11% |
| United States | 1 | 11% |
| Antarctica | 1 | 11% |
| Switzerland | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 2 | 22% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 217 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 34 | 16% |
| Student > Master | 27 | 12% |
| Researcher | 20 | 9% |
| Student > Ph. D. Student | 20 | 9% |
| Student > Doctoral Student | 12 | 6% |
| Other | 30 | 14% |
| Unknown | 74 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 18% |
| Biochemistry, Genetics and Molecular Biology | 27 | 12% |
| Agricultural and Biological Sciences | 19 | 9% |
| Immunology and Microbiology | 13 | 6% |
| Nursing and Health Professions | 12 | 6% |
| Other | 21 | 10% |
| Unknown | 85 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2018.
All research outputs
#6,335,799
of 25,382,440 outputs
Outputs from Journal of Diabetes Research
#237
of 1,139 outputs
Outputs of similar age
#91,899
of 328,544 outputs
Outputs of similar age from Journal of Diabetes Research
#5
of 23 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,139 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,544 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.