Title |
Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol
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Published in |
Nature Reviews Urology, October 2017
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DOI | 10.1038/nrurol.2017.163 |
Pubmed ID | |
Authors |
Marry M. van den Heuvel-Eibrink, Janna A. Hol, Kathy Pritchard-Jones, Harm van Tinteren, Rhoikos Furtwängler, Arnauld C. Verschuur, Gordan M. Vujanic, Ivo Leuschner, Jesper Brok, Christian Rübe, Anne M. Smets, Geert O. Janssens, Jan Godzinski, Gema L. Ramírez-Villar, Beatriz de Camargo, Heidi Segers, Paola Collini, Manfred Gessler, Christophe Bergeron, Filippo Spreafico, Norbert Graf |
Abstract |
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 33% |
Spain | 1 | 11% |
Nepal | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 89% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 206 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 33 | 16% |
Student > Master | 24 | 12% |
Student > Bachelor | 19 | 9% |
Student > Ph. D. Student | 18 | 9% |
Researcher | 14 | 7% |
Other | 53 | 26% |
Unknown | 45 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 103 | 50% |
Biochemistry, Genetics and Molecular Biology | 7 | 3% |
Unspecified | 7 | 3% |
Nursing and Health Professions | 6 | 3% |
Agricultural and Biological Sciences | 5 | 2% |
Other | 13 | 6% |
Unknown | 65 | 32% |