| Title |
Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients
|
|---|---|
| Published in |
Pediatric Blood and Cancer, December 2017
|
| DOI | 10.1002/pbc.26937 |
| Pubmed ID | |
| Authors |
Rachel Conyers, Subalatha Devaraja, David Elliott |
| Abstract |
Many paediatric patients with cancer experience significant chemotherapy side effects. Predisposition to drug reactions is governed by single nucleotide polymorphisms (SNPs). We performed a systematic review of the literature from 2006 through 2016. Outcomes of interest included patient characteristics, cancer type drug of interest, genes investigated, toxicity identified and genetic polymorphisms implicated. The primary toxicities studied were neurotoxicity cardiotoxicity, osteonecrosis, and thromboembolism and hypersensitivity reactions. The retrieved studies were grouped according to toxicity reported and SNP associations. This review highlights the discoveries to date in pharmacogenomics and paediatric oncology along with highlighting some of the important limitations in the area. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 33% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 15% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Student > Postgraduate | 6 | 10% |
| Student > Doctoral Student | 4 | 6% |
| Other | 13 | 21% |
| Unknown | 17 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 26% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 13% |
| Nursing and Health Professions | 5 | 8% |
| Agricultural and Biological Sciences | 3 | 5% |
| Other | 2 | 3% |
| Unknown | 19 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2017.
All research outputs
#8,066,835
of 25,658,541 outputs
Outputs from Pediatric Blood and Cancer
#1,241
of 6,073 outputs
Outputs of similar age
#148,905
of 450,880 outputs
Outputs of similar age from Pediatric Blood and Cancer
#33
of 131 outputs
Altmetric has tracked 25,658,541 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 6,073 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,880 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.