| Title |
Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries
|
|---|---|
| Published in |
Emerging Infectious Diseases, February 2015
|
| DOI | 10.3201/eid2101.140795 |
| Pubmed ID | |
| Authors |
Brianna Lindsay, Joe Oundo, M Anowar Hossain, Martin Antonio, Boubou Tamboura, Alan W Walker, Joseph N Paulson, Julian Parkhill, Richard Omore, Abu S G Faruque, Suman Kumar Das, Usman N Ikumapayi, Mitchell Adeyemi, Doh Sanogo, Debasish Saha, Samba Sow, Tamer H Farag, Dilruba Nasrin, Shan Li, Sandra Panchalingam, Myron M Levine, Karen Kotloff, Laurence S Magder, Laura Hungerford, Halvor Sommerfelt, Mihai Pop, James P Nataro, O Colin Stine |
| Abstract |
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 20% |
| Australia | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | <1% |
| Unknown | 110 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 23% |
| Student > Ph. D. Student | 18 | 16% |
| Student > Master | 14 | 13% |
| Other | 7 | 6% |
| Student > Bachelor | 6 | 5% |
| Other | 18 | 16% |
| Unknown | 22 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 22% |
| Immunology and Microbiology | 18 | 16% |
| Medicine and Dentistry | 13 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Nursing and Health Professions | 6 | 5% |
| Other | 10 | 9% |
| Unknown | 29 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2015.
All research outputs
#7,934,253
of 23,885,338 outputs
Outputs from Emerging Infectious Diseases
#5,600
of 9,348 outputs
Outputs of similar age
#109,768
of 358,767 outputs
Outputs of similar age from Emerging Infectious Diseases
#73
of 111 outputs
Altmetric has tracked 23,885,338 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.