| Title |
Whole metagenome sequencing reveals links between mosquito microbiota and insecticide resistance in malaria vectors
|
|---|---|
| Published in |
Scientific Reports, February 2018
|
| DOI | 10.1038/s41598-018-20367-4 |
| Pubmed ID | |
| Authors |
Nsa Dada, Mili Sheth, Kelly Liebman, Jesus Pinto, Audrey Lenhart |
| Abstract |
In light of the declining global malaria burden attained largely due to insecticides, a deeper understanding of the factors driving insecticide resistance is needed to mitigate its growing threat to malaria vector control programs. Following evidence of microbiota-mediated insecticide resistance in agricultural pests, we undertook a comparative study of the microbiota in mosquitoes of differing insecticide resistance status. The microbiota of wild-caught Anopheles albimanus, an important Latin American malaria vector, that were resistant (FEN_Res) or susceptible (FEN_Sus) to the organophosphate (OP) insecticide fenitrothion were characterized and compared using whole metagenome sequencing. Results showed differing composition of the microbiota and its functions between FEN_Res and FEN_Sus, with significant enrichment of OP-degrading bacteria and enzymes in FEN_Res compared to FEN_Sus. Lower bacterial diversity was observed in FEN_Res compared to FEN_Sus, suggesting the enrichment of bacterial taxa with a competitive advantage in response to insecticide selection pressure. We report and characterize for the first time whole metagenomes of An. albimanus, revealing associations between the microbiota and phenotypic resistance to the insecticide fenitrothion. This study lays the groundwork for further investigation of the role of the mosquito microbiota in insecticide resistance. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 29% |
| United Kingdom | 2 | 7% |
| Spain | 2 | 7% |
| Australia | 2 | 7% |
| India | 2 | 7% |
| Sri Lanka | 1 | 4% |
| Unknown | 11 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 14 | 50% |
| Members of the public | 12 | 43% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 216 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 17% |
| Researcher | 34 | 16% |
| Student > Master | 32 | 15% |
| Student > Bachelor | 30 | 14% |
| Student > Postgraduate | 11 | 5% |
| Other | 22 | 10% |
| Unknown | 51 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 32% |
| Biochemistry, Genetics and Molecular Biology | 41 | 19% |
| Immunology and Microbiology | 16 | 7% |
| Medicine and Dentistry | 9 | 4% |
| Environmental Science | 7 | 3% |
| Other | 12 | 6% |
| Unknown | 62 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2020.
All research outputs
#1,540,618
of 25,801,916 outputs
Outputs from Scientific Reports
#14,707
of 143,092 outputs
Outputs of similar age
#35,248
of 451,648 outputs
Outputs of similar age from Scientific Reports
#464
of 3,908 outputs
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