| Title |
Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome?
|
|---|---|
| Published in |
Prenatal Diagnosis, December 2017
|
| DOI | 10.1002/pd.5182 |
| Pubmed ID | |
| Authors |
Melissa Hill, Angela Barrett, Mahesh Choolani, Celine Lewis, Jane Fisher, Lyn S. Chitty |
| Abstract |
Implementation of non-invasive prenatal testing (NIPT) as a highly accurate aneuploidy screening test has raised questions around whether the high uptake may result in more terminations of pregnancies and fewer births of children with Down Syndrome (DS). Investigate the impact of NIPT on termination and live birth rates for DS. Literature reporting pregnancy outcomes following NIPT was reviewed. Termination rates were calculated for women with a high-risk NIPT result for DS. Two audits of pregnancy outcomes where NIPT indicated DS were conducted in England and Singapore. Fourteen studies, from the USA, Asia, Europe and the UK, were included in the review. Live births of children with DS were reported in eight studies. Termination rates following NIPT were unchanged or decreased when compared to termination rates prior to the introduction of NIPT. Audits found 15 of 43 women in the UK and two of six in Singapore continued pregnancies following a high-risk NIPT result. Termination rates following the detection of DS by NIPT are unchanged or decreased compared to historical termination rates. Impact on live birth rates may be minimal in settings where termination rates fall. Population-based studies are required to determine the true impact. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 25% |
| Netherlands | 2 | 17% |
| Italy | 1 | 8% |
| Belgium | 1 | 8% |
| Ireland | 1 | 8% |
| United Kingdom | 1 | 8% |
| Unknown | 3 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 139 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 17% |
| Student > Master | 21 | 15% |
| Other | 12 | 9% |
| Researcher | 12 | 9% |
| Student > Ph. D. Student | 10 | 7% |
| Other | 22 | 16% |
| Unknown | 39 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 23% |
| Biochemistry, Genetics and Molecular Biology | 21 | 15% |
| Nursing and Health Professions | 12 | 9% |
| Social Sciences | 6 | 4% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 18 | 13% |
| Unknown | 47 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 107. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2022.
All research outputs
#402,934
of 25,830,005 outputs
Outputs from Prenatal Diagnosis
#18
of 2,436 outputs
Outputs of similar age
#9,095
of 451,928 outputs
Outputs of similar age from Prenatal Diagnosis
#1
of 30 outputs
Altmetric has tracked 25,830,005 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,436 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,928 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.