| Title |
Detection of TR34/L98H CYP51A Mutation through Passive Surveillance for Azole-Resistant Aspergillus fumigatus in the United States from 2015 to 2017
|
|---|---|
| Published in |
Antimicrobial Agents and Chemotherapy, April 2018
|
| DOI | 10.1128/aac.02240-17 |
| Pubmed ID | |
| Authors |
Elizabeth L. Berkow, Natalie S. Nunnally, Alex Bandea, Randall Kuykendall, Karlyn Beer, Shawn R. Lockhart |
| Abstract |
Emergence of azole resistantAspergillus fumigatushas become a clinical problem in many parts of the world. Several amino acid mutations in the azole target protein, Cyp51Ap, contribute to this resistance, with the most concerning being the environmentally-derived TR34/L98H and TR46/Y121F/T289A mutations. Here, we performed passive surveillance to assess a sample of theA. fumigatuspopulation in the US for the presence of these mutations. We found 1.4% of those isolates to exhibit elevated MIC via broth microdilution and five of those isolates harbored the TR34/L98H mutation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 22% |
| Researcher | 5 | 14% |
| Student > Master | 5 | 14% |
| Student > Bachelor | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 10 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Immunology and Microbiology | 6 | 16% |
| Agricultural and Biological Sciences | 5 | 14% |
| Medicine and Dentistry | 4 | 11% |
| Unspecified | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 12 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2019.
All research outputs
#22,767,715
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Outputs from Antimicrobial Agents and Chemotherapy
#14,748
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Outputs of similar age
#299,602
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Outputs of similar age from Antimicrobial Agents and Chemotherapy
#228
of 233 outputs
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