| Title |
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
|
|---|---|
| Published in |
Nature Genetics, March 2018
|
| DOI | 10.1038/s41588-018-0079-y |
| Pubmed ID | |
| Authors |
Eleni Zengini, Konstantinos Hatzikotoulas, Ioanna Tachmazidou, Julia Steinberg, Fernando P. Hartwig, Lorraine Southam, Sophie Hackinger, Cindy G. Boer, Unnur Styrkarsdottir, Arthur Gilly, Daniel Suveges, Britt Killian, Thorvaldur Ingvarsson, Helgi Jonsson, George C. Babis, Andrew McCaskie, Andre G. Uitterlinden, Joyce B. J. van Meurs, Unnur Thorsteinsdottir, Kari Stefansson, George Davey Smith, Jeremy M. Wilkinson, Eleftheria Zeggini |
| Abstract |
Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biobank resource. After performing replication and meta-analysis in up to 30,727 cases and 297,191 controls, we identified nine new osteoarthritis loci, in all of which the most likely causal variant was noncoding. For three loci, we detected association with biologically relevant radiographic endophenotypes, and in five signals we identified genes that were differentially expressed in degraded compared with intact articular cartilage from patients with osteoarthritis. We established causal effects on osteoarthritis for higher body mass index but not for triglyceride levels or genetic predisposition to type 2 diabetes. |
X Demographics
The data shown below were collected from the profiles of 58 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 26% |
| United Kingdom | 9 | 16% |
| Germany | 2 | 3% |
| China | 2 | 3% |
| Brazil | 2 | 3% |
| Finland | 1 | 2% |
| Ireland | 1 | 2% |
| Spain | 1 | 2% |
| Australia | 1 | 2% |
| Other | 8 | 14% |
| Unknown | 16 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 57% |
| Scientists | 19 | 33% |
| Science communicators (journalists, bloggers, editors) | 3 | 5% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 279 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 279 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 60 | 22% |
| Researcher | 48 | 17% |
| Student > Master | 30 | 11% |
| Student > Bachelor | 21 | 8% |
| Student > Postgraduate | 12 | 4% |
| Other | 39 | 14% |
| Unknown | 69 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 78 | 28% |
| Medicine and Dentistry | 48 | 17% |
| Agricultural and Biological Sciences | 25 | 9% |
| Engineering | 11 | 4% |
| Nursing and Health Professions | 7 | 3% |
| Other | 24 | 9% |
| Unknown | 86 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 94. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2023.
All research outputs
#460,620
of 26,017,215 outputs
Outputs from Nature Genetics
#932
of 7,655 outputs
Outputs of similar age
#10,518
of 352,066 outputs
Outputs of similar age from Nature Genetics
#31
of 66 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,655 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.8. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.