Title |
Prioritizing complex disease risk genes by integrating multiple data
|
---|---|
Published in |
Genomics, April 2018
|
DOI | 10.1016/j.ygeno.2018.03.014 |
Pubmed ID | |
Authors |
Shanshan Guo, Benliang Wei, Bingchen Dong, Wan Li, Song Wu, Yuehan He, Yahui Wang, Xilei Zhao, Lina Chen, Weiming He |
Abstract |
Complex diseases, such as obesity, type II diabetes and chronic obstructive pulmonary disease (COPD) as metabolic disorder-related diseases are major concern for worldwide public health in the 21st century. The identification of these disease risk genes has attracted increasing interest in computational systems biology. In this paper, a novel method was proposed to prioritize disease risk genes (PDRG) by integrating functional annotations, protein interactions and gene expression information to assess similarity between genes in a disease-related metabolic network. The gene prioritization method was successfully carried out for obesity and COPD, the effectiveness of which was superior to those of ToppGene and ToppNet in both literature validation and recall rate by LOOCV. Our method could be applied broadly to other metabolism-related diseases, helping to prioritize novel disease risk genes, and could shed light on diagnosis and effective therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 31% |
Student > Master | 2 | 15% |
Student > Ph. D. Student | 1 | 8% |
Professor | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 31% |
Computer Science | 3 | 23% |
Nursing and Health Professions | 1 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Other | 0 | 0% |
Unknown | 3 | 23% |