| Title |
The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration
|
|---|---|
| Published in |
Neuropsychopharmacology, April 2015
|
| DOI | 10.1038/npp.2015.118 |
| Pubmed ID | |
| Authors |
Mark W Logue, Ananda B Amstadter, Dewleen G Baker, Laramie Duncan, Karestan C Koenen, Israel Liberzon, Mark W Miller, Rajendra A Morey, Caroline M Nievergelt, Kerry J Ressler, Alicia K Smith, Jordan W Smoller, Murray B Stein, Jennifer A Sumner, Monica Uddin |
| Abstract |
The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors. Although there have been some replicated candidates, the identification of risk variants for PTSD has lagged behind genetic research of other psychiatric disorders such as schizophrenia, autism and bipolar disorder. Psychiatric genetics has moved beyond examination of specific candidate genes in favor of the genome-wide association study (GWAS) strategy of very large numbers of samples, which allows for the discovery of previously unsuspected genes and molecular pathways. The successes of genetic studies of schizophrenia and bipolar disorder have been aided by the formation of a large-scale GWAS consortium: the Psychiatric Genomics Consortium (PGC). In contrast, only a handful of GWAS of PTSD have appeared in the literature to date. Here we describe the formation of a group dedicated to large-scale study of PTSD genetics: the PGC-PTSD. The PGC-PTSD faces challenges related to the contingency on trauma exposure and the large degree of ancestral genetic diversity within and across participating studies. Using the PGC analysis pipeline supplemented by analyses tailored to address these challenges, we anticipate that our first large-scale GWAS of PTSD will comprise over 10 000 cases and 30 000 trauma-exposed controls. Following in the footsteps of our PGC forerunners, this collaboration-of a scope that is unprecedented in the field of traumatic stress-will lead the search for replicable genetic associations and new insights into the biological underpinnings of PTSD.Neuropsychopharmacology accepted article preview online, 23 April 2015. doi:10.1038/npp.2015.118. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 40% |
| Ireland | 1 | 10% |
| Germany | 1 | 10% |
| India | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
| Scientists | 1 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Italy | 1 | <1% |
| Unknown | 207 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 18% |
| Researcher | 32 | 15% |
| Student > Master | 21 | 10% |
| Other | 14 | 7% |
| Student > Bachelor | 14 | 7% |
| Other | 37 | 18% |
| Unknown | 54 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 40 | 19% |
| Medicine and Dentistry | 29 | 14% |
| Neuroscience | 19 | 9% |
| Biochemistry, Genetics and Molecular Biology | 15 | 7% |
| Agricultural and Biological Sciences | 13 | 6% |
| Other | 29 | 14% |
| Unknown | 65 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2019.
All research outputs
#1,483,944
of 24,417,958 outputs
Outputs from Neuropsychopharmacology
#664
of 4,342 outputs
Outputs of similar age
#18,999
of 269,719 outputs
Outputs of similar age from Neuropsychopharmacology
#13
of 86 outputs
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