| Title |
Large Outbreak of Hepatitis C Virus Associated With Drug Diversion by a Healthcare Technician.
|
|---|---|
| Published in |
Clinical Infectious Diseases, May 2018
|
| DOI | 10.1093/cid/ciy193 |
| Pubmed ID | |
| Authors |
Sharon Alroy-Preis, Elizabeth R Daly, Christine Adamski, Jodie Dionne-Odom, Elizabeth A Talbot, Fengxiang Gao, Steffany J Cavallo, Katrina Hansen, Jennifer C Mahoney, Erin Metcalf, Carol Loring, Christine Bean, Jan Drobeniuc, Guo-Liang Xia, Saleem Kamili, José T Montero, Sarah Krycki, Karin Salome, Darlene Morse, Abigail Mathewson, Patricia Jackson, Maureen MacDonald, Jill Drouin, Pamela Hill, Marylee Greaves, Heather Barto, Ken Dufault, Kim Budde, John Dreisig, Benjamin Chan, Tracy Greene-Montfort, Natasha Khudyakov, Gilberto Vaughan, Joseph Forbi, Sumathi Ramachandran, Hong Thai, Lilia Ganova-Raeva, Yuri Khudyakov, Chong Gee Teo |
| Abstract |
In May 2012, the New Hampshire (NH) Division of Public Health Services (DPHS) was notified of 4 persons with newly diagnosed hepatitis C virus (HCV) infection at hospital X. Initial investigation suggested a common link to the hospital cardiac catheterization laboratory (CCL) because the infected persons included 3 CCL patients and a CCL technician. NH DPHS initiated an investigation to determine the source and control the outbreak. NH DPHS conducted site visits, case patient and employee interviews, medical record and medication use review, and employee and patient HCV testing using enzyme immunoassay for anti-HCV, reverse-transcription polymerase chain reaction for HCV RNA, nonstructural 5B (NS5B) and hypervariable region 1 (HVR1) sequencing, and quasispecies analysis. HCV HVR1 analysis of the first 4 cases confirmed a common source of infection. HCV testing identified 32 of 1074 CCL patients infected with the outbreak strain, including 3 patients coinfected with >1 HCV strain. The epidemiologic investigation revealed evidence of drug diversion by the HCV-infected technician, evidenced by gaps in controlled medication control, higher fentanyl use during procedures for confirmed cases, and building card key access records documenting the presence of the technician during days when transmission occurred. The employee's status as a traveling technician led to a multistate investigation, which identified additional cases at prior employment sites. This is the largest laboratory-confirmed drug diversion-associated HCV outbreak published to date. Recommendations to reduce drug diversion risk and to conduct outbreak investigations are provided. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 7 | 14% |
| United States | 5 | 10% |
| Israel | 2 | 4% |
| Poland | 1 | 2% |
| Unknown | 34 | 69% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 45 | 92% |
| Practitioners (doctors, other healthcare professionals) | 3 | 6% |
| Scientists | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 13% |
| Student > Doctoral Student | 3 | 10% |
| Student > Ph. D. Student | 3 | 10% |
| Student > Master | 3 | 10% |
| Student > Bachelor | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 13 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 26% |
| Nursing and Health Professions | 3 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Computer Science | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 14 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2023.
All research outputs
#1,104,449
of 25,257,066 outputs
Outputs from Clinical Infectious Diseases
#1,993
of 16,759 outputs
Outputs of similar age
#23,974
of 333,831 outputs
Outputs of similar age from Clinical Infectious Diseases
#33
of 213 outputs
Altmetric has tracked 25,257,066 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,759 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,831 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 213 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.