| Title |
The female urinary microbiome in urgency urinary incontinence
|
|---|---|
| Published in |
American Journal of Obstetrics & Gynecology, July 2015
|
| DOI | 10.1016/j.ajog.2015.07.009 |
| Pubmed ID | |
| Authors |
Meghan M. Pearce, Michael J. Zilliox, Amy B. Rosenfeld, Krystal J. Thomas-White, Holly E. Richter, Charles W. Nager, Anthony G. Visco, Ingrid E. Nygaard, Matthew D. Barber, Joseph Schaffer, Pamela Moalli, Vivian W. Sung, Ariana L. Smith, Rebecca Rogers, Tracy L. Nolen, Dennis Wallace, Susan F. Meikle, Xiaowu Gai, Alan J. Wolfe, Linda Brubaker, Pelvic Floor Disorders Network |
| Abstract |
To characterize the urinary microbiota in women planning treatment for urgency urinary incontinence and to describe clinical associations with urinary symptoms, urinary tract infection and treatment outcomes. Catheterized urine samples were collected from female multi-site randomized trial participants without clinical evidence of urinary tract infection and 16S rRNA gene sequencing was used to dichotomize participants as either DNA sequence-positive or sequence-negative. Associations with demographics, urinary symptoms, urinary tract infection risk, and treatment outcomes were determined. In sequence-positive samples, microbiotas were characterized on the basis of their dominant microorganisms. Over half [51.1% (93/182)] of the participants' urine samples were sequence-positive. Sequence-positive participants were younger (55.8 vs. 61.3, p=0.0007), had a higher body mass index (33.7 vs. 30.1, p=0.0009), had a higher mean baseline daily urgency urinary incontinence episodes (5.7 vs. 4.2, p<0.0001), responded better to treatment (decrease in urgency urinary incontinence episodes -4.4 vs. -3.3, p=0.0013) and were less likely to develop urinary tract infection (9% vs. 27%, p=0.0011). In sequence-positive samples, eight major bacterial clusters were identified; seven clusters were dominated by a single genus, most commonly Lactobacillus (45%) or Gardnerella (17%), but also other taxa (25%). The remaining cluster had no dominant genus (13%). DNA sequencing confirmed urinary bacterial DNA in many women without signs of infection and with urgency urinary incontinence. Sequence status was associated with baseline urgency urinary incontinence episodes, treatment response and post-treatment urinary tract infection risk. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 11% |
| India | 1 | 11% |
| Italy | 1 | 11% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 224 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 41 | 18% |
| Student > Bachelor | 23 | 10% |
| Other | 22 | 10% |
| Student > Master | 22 | 10% |
| Student > Ph. D. Student | 20 | 9% |
| Other | 47 | 21% |
| Unknown | 54 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 34% |
| Agricultural and Biological Sciences | 17 | 7% |
| Nursing and Health Professions | 15 | 7% |
| Biochemistry, Genetics and Molecular Biology | 14 | 6% |
| Immunology and Microbiology | 12 | 5% |
| Other | 31 | 14% |
| Unknown | 61 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2015.
All research outputs
#3,802,284
of 25,394,764 outputs
Outputs from American Journal of Obstetrics & Gynecology
#3,427
of 13,310 outputs
Outputs of similar age
#47,011
of 275,259 outputs
Outputs of similar age from American Journal of Obstetrics & Gynecology
#52
of 150 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,310 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 150 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.