| Title |
Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples
|
|---|---|
| Published in |
Science, July 2015
|
| DOI | 10.1126/science.aac4812 |
| Pubmed ID | |
| Authors |
Tal Korem, David Zeevi, Jotham Suez, Adina Weinberger, Tali Avnit-Sagi, Maya Pompan-Lotan, Elad Matot, Ghil Jona, Alon Harmelin, Nadav Cohen, Alexandra Sirota-Madi, Christoph A Thaiss, Meirav Pevsner-Fischer, Rotem Sorek, Ramnik Xavier, Eran Elinav, Eran Segal |
| Abstract |
Metagenomic sequencing increased our understanding of the role of the microbiome in health and disease, yet it only provides a snapshot of a highly dynamic ecosystem. Here, we show that the pattern of metagenomic sequencing read coverage for different microbial genomes contains a single trough and a single peak, the latter coinciding with the bacterial origin of replication. Furthermore, the ratio of sequencing coverage between the peak and trough provides a quantitative measure of a species' growth rate. We demonstrate this in vitro and in vivo, under different growth conditions, and in complex bacterial communities. For several bacterial species, peak-to-trough coverage ratios, but not relative abundances, correlated with the manifestation of inflammatory bowel disease and type II diabetes. |
X Demographics
The data shown below were collected from the profiles of 97 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 30 | 31% |
| United Kingdom | 6 | 6% |
| Germany | 4 | 4% |
| Israel | 4 | 4% |
| Spain | 3 | 3% |
| France | 3 | 3% |
| Canada | 2 | 2% |
| Comoros | 1 | 1% |
| China | 1 | 1% |
| Other | 9 | 9% |
| Unknown | 34 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 50 | 52% |
| Members of the public | 45 | 46% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,087 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 34 | 3% |
| Germany | 5 | <1% |
| Netherlands | 5 | <1% |
| United Kingdom | 4 | <1% |
| France | 3 | <1% |
| Denmark | 3 | <1% |
| Japan | 3 | <1% |
| Mexico | 3 | <1% |
| Brazil | 2 | <1% |
| Other | 13 | 1% |
| Unknown | 1012 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 264 | 24% |
| Student > Ph. D. Student | 251 | 23% |
| Student > Master | 110 | 10% |
| Student > Bachelor | 73 | 7% |
| Other | 46 | 4% |
| Other | 175 | 16% |
| Unknown | 168 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 366 | 34% |
| Biochemistry, Genetics and Molecular Biology | 202 | 19% |
| Immunology and Microbiology | 86 | 8% |
| Medicine and Dentistry | 67 | 6% |
| Environmental Science | 28 | 3% |
| Other | 120 | 11% |
| Unknown | 218 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 149. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2024.
All research outputs
#282,400
of 25,791,949 outputs
Outputs from Science
#7,690
of 83,344 outputs
Outputs of similar age
#2,972
of 275,834 outputs
Outputs of similar age from Science
#142
of 1,359 outputs
Altmetric has tracked 25,791,949 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,344 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.0. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 1,359 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.