| Title |
Effect of Antibiotic-Mediated Microbiome Modulation on Rotavirus Vaccine Immunogenicity: A Human, Randomized-Control Proof-of-Concept Trial
|
|---|---|
| Published in |
Cell Host & Microbe (Science Direct), August 2018
|
| DOI | 10.1016/j.chom.2018.07.005 |
| Pubmed ID | |
| Authors |
Vanessa C. Harris, Bastiaan W. Haak, Scott A. Handley, Baoming Jiang, Daniel E. Velasquez, Barry L. Hykes, Lindsay Droit, Guy A.M. Berbers, Elles Marleen Kemper, Ester M.M. van Leeuwen, Michael Boele van Hensbroek, Willem Joost Wiersinga |
| Abstract |
Rotavirus vaccines (RVV) protect against childhood gastroenteritis caused by rotavirus (RV) but have decreased effectiveness in low- and middle-income settings. This proof-of-concept, randomized-controlled, open-label trial tested if microbiome modulation can improve RVV immunogenicity. Healthy adults were randomized and administered broad-spectrum (oral vancomycin, ciprofloxacin, metronidazole), narrow-spectrum (vancomycin), or no antibiotics and then vaccinated with RVV, 21 per group per protocol. Baseline anti-RV IgA was high in all subjects. Although antibiotics did not alter absolute anti-RV IgA titers, RVV immunogenicity was boosted at 7 days in the narrow-spectrum group. Further, antibiotics increased fecal shedding of RV while also rapidly altering gut bacterial beta diversity. Beta diversity associated with RVV immunogenicity boosting at day 7 and specific bacterial taxa that distinguish RVV boosters and RV shedders were identified. Despite the negative primary endpoint, this study demonstrates that microbiota modification alters the immune response to RVV and supports further exploration of microbiome manipulation to improve RVV immunogenicity. |
X Demographics
The data shown below were collected from the profiles of 88 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 20% |
| France | 7 | 8% |
| United Kingdom | 7 | 8% |
| Australia | 3 | 3% |
| Netherlands | 2 | 2% |
| Ireland | 2 | 2% |
| Thailand | 1 | 1% |
| Mexico | 1 | 1% |
| Kenya | 1 | 1% |
| Other | 9 | 10% |
| Unknown | 37 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 55 | 63% |
| Scientists | 25 | 28% |
| Practitioners (doctors, other healthcare professionals) | 5 | 6% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 197 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 15% |
| Student > Master | 29 | 15% |
| Student > Ph. D. Student | 27 | 14% |
| Student > Bachelor | 20 | 10% |
| Student > Doctoral Student | 14 | 7% |
| Other | 30 | 15% |
| Unknown | 47 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 16% |
| Immunology and Microbiology | 31 | 16% |
| Agricultural and Biological Sciences | 24 | 12% |
| Medicine and Dentistry | 21 | 11% |
| Nursing and Health Professions | 7 | 4% |
| Other | 25 | 13% |
| Unknown | 58 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 88. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2021.
All research outputs
#493,732
of 25,801,916 outputs
Outputs from Cell Host & Microbe (Science Direct)
#366
of 2,658 outputs
Outputs of similar age
#10,430
of 343,042 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#9
of 53 outputs
Altmetric has tracked 25,801,916 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,658 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,042 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.