| Title |
Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
|
|---|---|
| Published in |
eLife, September 2018
|
| DOI | 10.7554/elife.37294 |
| Pubmed ID | |
| Authors |
Haley Hieronymus, Rajmohan Murali, Amy Tin, Kamlesh Yadav, Wassim Abida, Henrik Moller, Daniel Berney, Howard Scher, Brett Carver, Peter Scardino, Nikolaus Schultz, Barry Taylor, Andrew Vickers, Jack Cuzick, Charles L Sawyers |
| Abstract |
The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is associated with recurrence of primary prostate cancer. Whether CNA burden is associated with prostate cancer survival or outcomes in other cancers is unknown. We analyzed the CNA landscape of conservatively treated prostate cancer in a biopsy and transurethral resection cohort, reflecting an increasingly common treatment approach. We find that CNA burden is prognostic for cancer-specific death, independent of standard clinical prognostic factors. More broadly, we find CNA burden is significantly associated with disease-free and overall survival in primary breast, endometrial, renal clear cell, thyroid, and colorectal cancer in TCGA cohorts. To assess clinical applicability, we validated these findings in an independent pan-cancer cohort of patients whose tumors were sequenced using a clinically-certified next generation sequencing assay (MSK-IMPACT), where prognostic value varied based on cancer type. This prognostic association was affected by incorporating tumor purity in some cohorts. Overall, CNA burden of primary and metastatic tumors is a prognostic factor, potentially modulated by sample purity and measurable by current clinical sequencing. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 41% |
| Switzerland | 3 | 9% |
| United Kingdom | 2 | 6% |
| Singapore | 1 | 3% |
| China | 1 | 3% |
| Korea, Republic of | 1 | 3% |
| Turkey | 1 | 3% |
| Comoros | 1 | 3% |
| Japan | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 9 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 16 | 47% |
| Members of the public | 13 | 38% |
| Science communicators (journalists, bloggers, editors) | 3 | 9% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 214 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 41 | 19% |
| Student > Ph. D. Student | 37 | 17% |
| Student > Bachelor | 18 | 8% |
| Student > Master | 15 | 7% |
| Student > Doctoral Student | 14 | 7% |
| Other | 30 | 14% |
| Unknown | 59 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 62 | 29% |
| Medicine and Dentistry | 31 | 14% |
| Agricultural and Biological Sciences | 23 | 11% |
| Computer Science | 11 | 5% |
| Engineering | 4 | 2% |
| Other | 13 | 6% |
| Unknown | 70 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 138. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2023.
All research outputs
#299,233
of 25,383,344 outputs
Outputs from eLife
#758
of 15,549 outputs
Outputs of similar age
#6,242
of 341,938 outputs
Outputs of similar age from eLife
#20
of 342 outputs
Altmetric has tracked 25,383,344 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,549 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.1. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 342 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.