| Title |
Healthy Lifestyle Factors Associated With Lower Risk of Colorectal Cancer Irrespective of Genetic Risk
|
|---|---|
| Published in |
Gastroenterology, September 2018
|
| DOI | 10.1053/j.gastro.2018.08.044 |
| Pubmed ID | |
| Authors |
Prudence R Carr, Korbinian Weigl, Lina Jansen, Viola Walter, Vanessa Erben, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister |
| Abstract |
The combined effects of healthy lifestyle factors on colorectal cancer (CRC) risk are unclear. We aimed to develop a healthy lifestyle score, to investigate the joint effects of modifiable lifestyle factors on reduction of CRC risk and determine whether associations differ with genetic risk. We collected data from a large population-based case-control study in Germany and used multiple logistic regression analyses to examine associations between the healthy lifestyle score (derived from 5 modifiable lifestyle factors: smoking, alcohol consumption, diet, physical activity, and body fatness) and CRC risk. We created a genetic risk score, based on 53 risk variants, to investigate the association of the healthy lifestyle score and risk of CRC, stratified by genetic risk. We included 4092 patients with CRC and 3032 individuals without CRC (controls) in our analysis. In adjusted models, compared to participants with 0 or 1 healthy lifestyle factor, participants with 2 (OR, 0.85; 95% CI, 0.67-1.06), 3 (OR, 0.62; 95% CI, 0.50-0.77), 4 (OR, 0.53; 95% CI, 0.42-0.66), or 5 (OR, 0.33; 95% CI, 0.26-0.43) healthy lifestyle factors had increasingly lower risks of CRC (P trend <.0001). We found no differences among subgroups stratified by genetic risk score, history of colonoscopy, or family history of CRC. Overall, 45% of CRC cases (95% CI, 34%-53%) could be attributed to non-adherence to all 5 healthy lifestyle behaviors. In a large population-based case-control study, we identified a combination of lifestyle factors that appears to reduce risk of CRC, regardless of the patient's genetic profile. These results reinforce the importance of primary prevention of CRC. |
X Demographics
The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 21 | 30% |
| United Kingdom | 4 | 6% |
| Germany | 4 | 6% |
| Australia | 2 | 3% |
| United States | 2 | 3% |
| Mexico | 2 | 3% |
| Chile | 2 | 3% |
| Colombia | 1 | 1% |
| Grenada | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 25 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 53 | 77% |
| Practitioners (doctors, other healthcare professionals) | 7 | 10% |
| Scientists | 6 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
| Unknown | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 149 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 13% |
| Student > Bachelor | 17 | 11% |
| Researcher | 12 | 8% |
| Other | 11 | 7% |
| Student > Ph. D. Student | 11 | 7% |
| Other | 24 | 16% |
| Unknown | 54 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 24% |
| Nursing and Health Professions | 17 | 11% |
| Biochemistry, Genetics and Molecular Biology | 9 | 6% |
| Agricultural and Biological Sciences | 6 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 15 | 10% |
| Unknown | 61 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2022.
All research outputs
#675,346
of 25,820,938 outputs
Outputs from Gastroenterology
#564
of 12,400 outputs
Outputs of similar age
#14,220
of 347,334 outputs
Outputs of similar age from Gastroenterology
#14
of 149 outputs
Altmetric has tracked 25,820,938 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,400 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.