| Title |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies
|
|---|---|
| Published in |
Gut, December 2015
|
| DOI | 10.1136/gutjnl-2015-310612 |
| Pubmed ID | |
| Authors |
Zhaoming Wang, Juncheng Dai, Nan Hu, Xiaoping Miao, Christian C Abnet, Ming Yang, Neal D Freedman, Jinfei Chen, Laurie Burdette, Xun Zhu, Charles C Chung, Chuanli Ren, Sanford M Dawsey, Meilin Wang, Ti Ding, Jiangbo Du, Yu-Tang Gao, Rong Zhong, Carol Giffen, Wenting Pan, Woon-Puay Koh, Ningbing Dai, Linda M Liao, Caiwang Yan, You-Lin Qiao, Yue Jiang, Xiao-Ou Shu, Jiaping Chen, Chaoyu Wang, Hongxia Ma, Hua Su, Zhendong Zhang, Lemin Wang, Chen Wu, Yong-Bing Xiang, Zhibin Hu, Jian-Min Yuan, Lu Xie, Wei Zheng, Dongxin Lin, Stephen J Chanock, Yongyong Shi, Alisa M Goldstein, Guangfu Jin, Philip R Taylor, Hongbing Shen |
| Abstract |
Although several genome-wide association studies (GWAS) of non-cardia gastric cancer have been published, more novel association signals could be exploited by combining individual studies together, which will further elucidate the genetic susceptibility of non-cardia gastric cancer. We conducted a meta-analysis of two published Chinese GWAS studies (2031 non-cardia gastric cancer cases and 4970 cancer-free controls) and followed by genotyping of additional 3564 cases and 4637 controls in two stages. The overall meta-analysis revealed two new association signals. The first was a novel locus at 5q14.3 and marked by rs7712641 (per-allele OR=0.84, 95% CI 0.80 to 0.88; p=1.21×10(-11)). This single-nucleotide polymorphism (SNP) marker maps to the intron of the long non-coding RNA, lnc-POLR3G-4 (XLOC_004464), which we observed has lower expression in non-cardia gastric tumour compared with matched normal tissue (Pwilcoxon signed-rank=7.20×10(-4)). We also identified a new signal at the 1q22 locus, rs80142782 (per-allele OR=0.62; 95% CI 0.56 to 0.69; p=1.71×10(-19)), which was independent of the previously reported SNP at the same locus, rs4072037 (per-allele OR=0.74; 95% CI 0.69 to 0.79; p=6.28×10(-17)). Analysis of the new SNP conditioned on the known SNP showed that the new SNP remained genome-wide significant (Pconditional=3.47×10(-8)). Interestingly, rs80142782 has a minor allele frequency of 0.05 in East Asians but is monomorphic in both European and African populations. These findings add new evidence for inherited genetic susceptibility to non-cardia gastric cancer and provide further clues to its aetiology in the Han Chinese population. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| United Kingdom | 1 | 33% |
| Germany | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 20% |
| Researcher | 7 | 15% |
| Professor | 4 | 9% |
| Other | 3 | 7% |
| Student > Postgraduate | 3 | 7% |
| Other | 10 | 22% |
| Unknown | 10 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 37% |
| Agricultural and Biological Sciences | 6 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 13% |
| Nursing and Health Professions | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 11 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2016.
All research outputs
#2,822,966
of 22,836,570 outputs
Outputs from Gut
#1,559
of 6,834 outputs
Outputs of similar age
#50,025
of 390,595 outputs
Outputs of similar age from Gut
#25
of 66 outputs
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