| Title |
Single-cell genome sequencing: current state of the science
|
|---|---|
| Published in |
Nature Reviews Genetics, January 2016
|
| DOI | 10.1038/nrg.2015.16 |
| Pubmed ID | |
| Authors |
Charles Gawad, Winston Koh, Stephen R. Quake |
| Abstract |
The field of single-cell genomics is advancing rapidly and is generating many new insights into complex biological systems, ranging from the diversity of microbial ecosystems to the genomics of human cancer. In this Review, we provide an overview of the current state of the field of single-cell genome sequencing. First, we focus on the technical challenges of making measurements that start from a single molecule of DNA, and then explore how some of these recent methodological advancements have enabled the discovery of unexpected new biology. Areas highlighted include the application of single-cell genomics to interrogate microbial dark matter and to evaluate the pathogenic roles of genetic mosaicism in multicellular organisms, with a focus on cancer. We then attempt to predict advances we expect to see in the next few years. |
X Demographics
The data shown below were collected from the profiles of 125 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 25 | 20% |
| United Kingdom | 15 | 12% |
| France | 8 | 6% |
| Canada | 6 | 5% |
| Spain | 5 | 4% |
| Germany | 5 | 4% |
| India | 3 | 2% |
| Colombia | 2 | 2% |
| Saudi Arabia | 2 | 2% |
| Other | 16 | 13% |
| Unknown | 38 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 67 | 54% |
| Members of the public | 56 | 45% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 2,792 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 34 | 1% |
| United Kingdom | 13 | <1% |
| Germany | 11 | <1% |
| Spain | 7 | <1% |
| Japan | 6 | <1% |
| France | 4 | <1% |
| Denmark | 4 | <1% |
| Chile | 3 | <1% |
| Canada | 3 | <1% |
| Other | 36 | 1% |
| Unknown | 2671 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 712 | 26% |
| Researcher | 570 | 20% |
| Student > Master | 312 | 11% |
| Student > Bachelor | 262 | 9% |
| Student > Doctoral Student | 133 | 5% |
| Other | 395 | 14% |
| Unknown | 408 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 822 | 29% |
| Biochemistry, Genetics and Molecular Biology | 776 | 28% |
| Medicine and Dentistry | 178 | 6% |
| Engineering | 115 | 4% |
| Computer Science | 98 | 4% |
| Other | 337 | 12% |
| Unknown | 466 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 132. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#319,636
of 25,706,302 outputs
Outputs from Nature Reviews Genetics
#140
of 2,743 outputs
Outputs of similar age
#5,650
of 407,595 outputs
Outputs of similar age from Nature Reviews Genetics
#2
of 42 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,743 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.5. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.