| Title |
Dosing recommendations for pharmacogenetic interactions related to drug metabolism
|
|---|---|
| Published in |
Pharmacogenetics and Genomics, July 2016
|
| DOI | 10.1097/fpc.0000000000000220 |
| Pubmed ID | |
| Authors |
Kelly K. Filipski, Michael A. Pacanowski, Anuradha Ramamoorthy, William Gregory Feero, Andrew N. Freedman |
| Abstract |
Pharmacogenomic studies have established the important contribution of drug-metabolizing enzyme genotype toward drug toxicity and treatment failure; however, clinical implementation of pharmacogenomics has been slow. The aim of this study was to systematically review the information on drug-metabolizing enzyme pharmacogenomics available in the US drug labeling, practice guidelines, and recommendations. Drug-metabolizing enzyme genotype and phenotype information was assessed in US FDA drug labeling, clinical practice guidelines, and independent technology assessors to evaluate the consistency in information sources for healthcare providers. Eighty four gene-drug pairs were identified as having drug-metabolizing enzyme genotype or phenotype information within the label. The manner in which pharmacogenomic information was presented was heterogeneous both within the label and between clinical practice recommendations. For proper implementation of pharmacogenomics in clinical practice, information sources for healthcare providers should relay consistent and clear information for the appropriate use of biomarkers. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 10 | 48% |
| Venezuela, Bolivarian Republic of | 2 | 10% |
| United States | 1 | 5% |
| Unknown | 8 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 52% |
| Practitioners (doctors, other healthcare professionals) | 8 | 38% |
| Scientists | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| France | 1 | 3% |
| Unknown | 32 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 7 | 21% |
| Researcher | 7 | 21% |
| Student > Master | 4 | 12% |
| Librarian | 2 | 6% |
| Student > Ph. D. Student | 2 | 6% |
| Other | 7 | 21% |
| Unknown | 5 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 21% |
| Biochemistry, Genetics and Molecular Biology | 5 | 15% |
| Agricultural and Biological Sciences | 3 | 9% |
| Nursing and Health Professions | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2023.
All research outputs
#2,457,182
of 26,017,215 outputs
Outputs from Pharmacogenetics and Genomics
#44
of 1,280 outputs
Outputs of similar age
#42,515
of 373,353 outputs
Outputs of similar age from Pharmacogenetics and Genomics
#2
of 16 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,280 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.