Title |
Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
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Published in |
BMC Medical Genomics, April 2012
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DOI | 10.1186/1471-2350-13-30 |
Pubmed ID | |
Authors |
Jonna L Grimsby, Bianca C Porneala, Jason L Vassy, Quanhe Yang, José C Florez, Josée Dupuis, Tiebin Liu, Ajay Yesupriya, Man-Huei Chang, Renee M Ned, Nicole F Dowling, Muin J Khoury, James B Meigs, the MAGIC Investigators |
Abstract |
Hemoglobin A1c (HbA1c) levels diagnose diabetes, predict mortality and are associated with ten single nucleotide polymorphisms (SNPs) in white individuals. Genetic associations in other race groups are not known. We tested the hypotheses that there is race-ethnic variation in 1) HbA1c-associated risk allele frequencies (RAFs) for SNPs near SPTA1, HFE, ANK1, HK1, ATP11A, FN3K, TMPRSS6, G6PC2, GCK, MTNR1B; 2) association of SNPs with HbA1c and 3) association of SNPs with mortality. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 2% |
United States | 1 | 2% |
Germany | 1 | 2% |
Unknown | 49 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 17% |
Researcher | 9 | 17% |
Student > Ph. D. Student | 8 | 15% |
Other | 4 | 8% |
Student > Bachelor | 4 | 8% |
Other | 9 | 17% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 27% |
Agricultural and Biological Sciences | 10 | 19% |
Nursing and Health Professions | 5 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Computer Science | 2 | 4% |
Other | 4 | 8% |
Unknown | 14 | 27% |