| Title |
Risk Estimations, Risk Factors, and Genetic Variants Associated with Alzheimer's Disease in Selected Publications from the Framingham Heart Study
|
|---|---|
| Published in |
Journal of Alzheimer's Disease, January 2013
|
| DOI | 10.3233/jad-2012-129040 |
| Pubmed ID | |
| Authors |
Galit Weinstein, Philip A. Wolf, Alexa S. Beiser, Rhoda Au, Sudha Seshadri |
| Abstract |
The study of Alzheimer's disease (AD) in the Framingham Heart Study (FHS), a multi-generational, community-based population study, began nearly four decades ago. In this overview, we highlight findings from seven prior publications that examined lifetime risk estimates for AD, environmental risk factors for AD, circulating and imaging markers of aging-related brain injury, and explorations on the genetics underlying AD. First, we describe estimations of the lifetime risk of AD. These estimates are distinguished from other measures of disease burden and have substantial public health implications. We then describe prospective studies of environmental AD risk factors: one examined the association between plasma levels of omega-3 fatty-acid and risk of incident AD, the other explored the association of diabetes to this risk in subsamples with specific characteristics. With evidence of inflammation as an underlying mechanism, we also describe findings from a study that compared the effects of serum cytokines and spontaneous production of peripheral blood mononuclear cell cytokines on AD risk. Investigating AD related endophenotypes increases sensitivity in identifying risk factors and can be used to explore pathophysiologic pathways between a risk factor and the disease. We describe findings of an association between large volume of white matter hyperintensities and a specific pattern of cognitive deficits in non-demented participants. Finally, we summarize our findings from two genetic studies: The first used genome-wide association (GWA) and family-based association methods to explore the genetic basis of cognitive and structural brain traits. The second is a large meta-analysis GWA study of AD, in which novel loci of AD susceptibility were found. Together, these findings demonstrate the FHS multi-directional efforts in investigating dementia and AD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Australia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 68 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 20% |
| Student > Master | 8 | 12% |
| Other | 7 | 10% |
| Student > Bachelor | 6 | 9% |
| Student > Postgraduate | 6 | 9% |
| Other | 12 | 17% |
| Unknown | 16 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 28% |
| Agricultural and Biological Sciences | 10 | 14% |
| Psychology | 6 | 9% |
| Neuroscience | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Other | 6 | 9% |
| Unknown | 19 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2019.
All research outputs
#16,051,091
of 25,377,790 outputs
Outputs from Journal of Alzheimer's Disease
#6,485
of 7,452 outputs
Outputs of similar age
#180,271
of 289,014 outputs
Outputs of similar age from Journal of Alzheimer's Disease
#139
of 185 outputs
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